ID   SECM_ECOK1              Reviewed;         170 AA.
AC   A1A7E2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Secretion monitor {ECO:0000255|HAMAP-Rule:MF_01332};
DE   Flags: Precursor;
GN   Name=secM {ECO:0000255|HAMAP-Rule:MF_01332}; OrderedLocusNames=Ecok1_00880;
GN   ORFNames=APECO1_1889;
OS   Escherichia coli O1:K1 / APEC.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=405955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17293413; DOI=10.1128/jb.01726-06;
RA   Johnson T.J., Kariyawasam S., Wannemuehler Y., Mangiamele P., Johnson S.J.,
RA   Doetkott C., Skyberg J.A., Lynne A.M., Johnson J.R., Nolan L.K.;
RT   "The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7
RT   shares strong similarities with human extraintestinal pathogenic E. coli
RT   genomes.";
RL   J. Bacteriol. 189:3228-3236(2007).
CC   -!- FUNCTION: Regulates secA expression by translational coupling of the
CC       secM secA operon. Translational pausing at a specific Pro residue 5
CC       residues before the end of the protein may allow disruption of a mRNA
CC       repressor helix that normally suppresses secA translation initiation.
CC       {ECO:0000255|HAMAP-Rule:MF_01332}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-
CC       Rule:MF_01332}. Periplasm {ECO:0000255|HAMAP-Rule:MF_01332}. Note=The
CC       active form is cytosolic, while the periplasmic form is rapidly
CC       degraded, mainly by the tail-specific protease. {ECO:0000255|HAMAP-
CC       Rule:MF_01332}.
CC   -!- SIMILARITY: Belongs to the SecM family. {ECO:0000255|HAMAP-
CC       Rule:MF_01332}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABI99581.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000468; ABI99581.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000014320.1; NC_008563.1.
DR   AlphaFoldDB; A1A7E2; -.
DR   EnsemblBacteria; ABI99581; ABI99581; APECO1_1889.
DR   GeneID; 58460763; -.
DR   KEGG; ecv:APECO1_1889; -.
DR   HOGENOM; CLU_108853_0_0_6; -.
DR   Proteomes; UP000008216; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR   HAMAP; MF_01332; SecM; 1.
DR   InterPro; IPR009502; SecM.
DR   Pfam; PF06558; SecM; 1.
DR   PIRSF; PIRSF004572; SecM; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Periplasm; Signal.
FT   SIGNAL          1..37
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01332"
FT   CHAIN           38..170
FT                   /note="Secretion monitor"
FT                   /id="PRO_0000314445"
SQ   SEQUENCE   170 AA;  18866 MW;  5B4B3001056CAD22 CRC64;
     MSGILTRWRQ FGKRYFWPHL LLGMVAASLG LPALSNAAEP NAPAKATTRN HEPSAKVNFG
     QLALLEANTR RPNSNYSVDY WHQHAIRTVI RHLSFAMAPQ TLPVAEESLP LQAQHLALLD
     TLSALLTQEG TPSEKGYRID YAHFTPQAKF STPVWISQAQ GIRAGPQRLS