SECM_ECOUT
ID SECM_ECOUT Reviewed; 170 AA.
AC Q1RG98;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Secretion monitor {ECO:0000255|HAMAP-Rule:MF_01332};
DE Flags: Precursor;
GN Name=secM {ECO:0000255|HAMAP-Rule:MF_01332}; OrderedLocusNames=UTI89_C0106;
OS Escherichia coli (strain UTI89 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=364106;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UTI89 / UPEC;
RX PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S.,
RA Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J.,
RA Gordon J.I.;
RT "Identification of genes subject to positive selection in uropathogenic
RT strains of Escherichia coli: a comparative genomics approach.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC -!- FUNCTION: Regulates secA expression by translational coupling of the
CC secM secA operon. Translational pausing at a specific Pro residue 5
CC residues before the end of the protein may allow disruption of a mRNA
CC repressor helix that normally suppresses secA translation initiation.
CC {ECO:0000255|HAMAP-Rule:MF_01332}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-
CC Rule:MF_01332}. Periplasm {ECO:0000255|HAMAP-Rule:MF_01332}. Note=The
CC active form is cytosolic, while the periplasmic form is rapidly
CC degraded, mainly by the tail-specific protease. {ECO:0000255|HAMAP-
CC Rule:MF_01332}.
CC -!- SIMILARITY: Belongs to the SecM family. {ECO:0000255|HAMAP-
CC Rule:MF_01332}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABE05616.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000243; ABE05616.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_000014320.1; NC_007946.1.
DR AlphaFoldDB; Q1RG98; -.
DR EnsemblBacteria; ABE05616; ABE05616; UTI89_C0106.
DR GeneID; 58460763; -.
DR KEGG; eci:UTI89_C0106; -.
DR HOGENOM; CLU_108853_0_0_6; -.
DR OMA; NYWQQHA; -.
DR Proteomes; UP000001952; Chromosome.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR HAMAP; MF_01332; SecM; 1.
DR InterPro; IPR009502; SecM.
DR Pfam; PF06558; SecM; 1.
DR PIRSF; PIRSF004572; SecM; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Periplasm; Signal.
FT SIGNAL 1..37
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01332"
FT CHAIN 38..170
FT /note="Secretion monitor"
FT /id="PRO_0000314444"
SQ SEQUENCE 170 AA; 18866 MW; 5B4B3001056CAD22 CRC64;
MSGILTRWRQ FGKRYFWPHL LLGMVAASLG LPALSNAAEP NAPAKATTRN HEPSAKVNFG
QLALLEANTR RPNSNYSVDY WHQHAIRTVI RHLSFAMAPQ TLPVAEESLP LQAQHLALLD
TLSALLTQEG TPSEKGYRID YAHFTPQAKF STPVWISQAQ GIRAGPQRLS