ID   SECM_KLEP7              Reviewed;         165 AA.
AC   A6T4P0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Secretion monitor {ECO:0000255|HAMAP-Rule:MF_01332};
DE   Flags: Precursor;
GN   Name=secM {ECO:0000255|HAMAP-Rule:MF_01332};
GN   OrderedLocusNames=KPN78578_01000; ORFNames=KPN_00101;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates secA expression by translational coupling of the
CC       secM secA operon. Translational pausing at a specific Pro residue 5
CC       residues before the end of the protein may allow disruption of a mRNA
CC       repressor helix that normally suppresses secA translation initiation.
CC       {ECO:0000255|HAMAP-Rule:MF_01332}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-
CC       Rule:MF_01332}. Periplasm {ECO:0000255|HAMAP-Rule:MF_01332}. Note=The
CC       active form is cytosolic, while the periplasmic form is rapidly
CC       degraded, mainly by the tail-specific protease. {ECO:0000255|HAMAP-
CC       Rule:MF_01332}.
CC   -!- SIMILARITY: Belongs to the SecM family. {ECO:0000255|HAMAP-
CC       Rule:MF_01332}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABR75561.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000647; ABR75561.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; A6T4P0; -.
DR   SMR; A6T4P0; -.
DR   STRING; 272620.KPN_00101; -.
DR   EnsemblBacteria; ABR75561; ABR75561; KPN_00101.
DR   KEGG; kpn:KPN_00101; -.
DR   HOGENOM; CLU_108853_0_0_6; -.
DR   OMA; NYWQQHA; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR   HAMAP; MF_01332; SecM; 1.
DR   InterPro; IPR009502; SecM.
DR   Pfam; PF06558; SecM; 1.
DR   PIRSF; PIRSF004572; SecM; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Periplasm; Reference proteome; Signal.
FT   SIGNAL          1..37
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01332"
FT   CHAIN           38..165
FT                   /note="Secretion monitor"
FT                   /id="PRO_0000314447"
SQ   SEQUENCE   165 AA;  18121 MW;  ED755C72C4532B06 CRC64;
     MSGLLTRWRQ FGRRYFWPHL LLGMVAASLG LPALSNGHET AAPAKATASN HNPSKVNFSQ
     LALLETNRRP SFTVDYWHQH AIRTVIRHLS FAMAPQALPV AEETSPLQAQ HLALLDTLSA
     LLTQDSTPPV VIRQAGYIPS SYSAFRVSAW ISQVAGIRAG PQRLS