ID   SECM_PROMH              Reviewed;         175 AA.
AC   B4F103;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Secretion monitor {ECO:0000255|HAMAP-Rule:MF_01332};
DE   Flags: Precursor;
GN   Name=secM {ECO:0000255|HAMAP-Rule:MF_01332}; OrderedLocusNames=PMI2062;
OS   Proteus mirabilis (strain HI4320).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=529507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HI4320;
RX   PubMed=18375554; DOI=10.1128/jb.01981-07;
RA   Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S.,
RA   Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T.,
RA   Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA   Rabbinowitsch E., Walker D., Whithead S., Thomson N.R., Rather P.N.,
RA   Parkhill J., Mobley H.L.T.;
RT   "Complete genome sequence of uropathogenic Proteus mirabilis, a master of
RT   both adherence and motility.";
RL   J. Bacteriol. 190:4027-4037(2008).
CC   -!- FUNCTION: Regulates secA expression by translational coupling of the
CC       secM secA operon. Translational pausing at a specific Pro residue 5
CC       residues before the end of the protein may allow disruption of a mRNA
CC       repressor helix that normally suppresses secA translation initiation.
CC       {ECO:0000255|HAMAP-Rule:MF_01332}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-
CC       Rule:MF_01332}. Periplasm {ECO:0000255|HAMAP-Rule:MF_01332}. Note=The
CC       active form is cytosolic, while the periplasmic form is rapidly
CC       degraded, mainly by the tail-specific protease. {ECO:0000255|HAMAP-
CC       Rule:MF_01332}.
CC   -!- SIMILARITY: Belongs to the SecM family. {ECO:0000255|HAMAP-
CC       Rule:MF_01332}.
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DR   EMBL; AM942759; CAR44131.1; -; Genomic_DNA.
DR   RefSeq; WP_004244104.1; NC_010554.1.
DR   AlphaFoldDB; B4F103; -.
DR   STRING; 529507.PMI2062; -.
DR   EnsemblBacteria; CAR44131; CAR44131; PMI2062.
DR   GeneID; 6802852; -.
DR   KEGG; pmr:PMI2062; -.
DR   eggNOG; ENOG5031JGK; Bacteria.
DR   HOGENOM; CLU_108853_0_0_6; -.
DR   OMA; NYWQQHA; -.
DR   Proteomes; UP000008319; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR   HAMAP; MF_01332; SecM; 1.
DR   InterPro; IPR009502; SecM.
DR   Pfam; PF06558; SecM; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Periplasm; Reference proteome; Signal.
FT   SIGNAL          1..38
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01332"
FT   CHAIN           39..175
FT                   /note="Secretion monitor"
FT                   /id="PRO_1000166099"
SQ   SEQUENCE   175 AA;  19534 MW;  264B02A28BAE5C6E CRC64;
     MSIINFWRQF GRRYFWSHLL LGMVAAGIGM PSLVSAHAEN PSQTDTPSSQ NRQSQALIAF
     DNLFLRQSVQ NPASSFTFNY WQQHAVKNVI KQLSFAFTIH SPELMVKAKD EPSPVANVAE
     VMLDTLYALL TQAPSSTLVN LPISRGVLTE NRISYHTGLW LAQIRGIRAG PYLTA