ID   SECM_SALTI              Reviewed;         165 AA.
AC   Q8Z9G4;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Secretion monitor {ECO:0000255|HAMAP-Rule:MF_01332};
DE   Flags: Precursor;
GN   Name=secM {ECO:0000255|HAMAP-Rule:MF_01332};
GN   OrderedLocusNames=STY0155, t0139;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
RN   [3]
RP   IDENTIFICATION OF START CODON.
RX   PubMed=10986266; DOI=10.1128/jb.182.19.5592-5595.2000;
RA   Sarker S., Rudd K.E., Oliver D.B.;
RT   "Revised translation start site for secM defines an atypical signal peptide
RT   that regulates Escherichia coli secA expression.";
RL   J. Bacteriol. 182:5592-5595(2000).
CC   -!- FUNCTION: Regulates secA expression by translational coupling of the
CC       secM secA operon. Translational pausing at a specific Pro residue 5
CC       residues before the end of the protein may allow disruption of a mRNA
CC       repressor helix that normally suppresses secA translation initiation.
CC       {ECO:0000255|HAMAP-Rule:MF_01332}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-
CC       Rule:MF_01332}. Periplasm {ECO:0000255|HAMAP-Rule:MF_01332}. Note=The
CC       active form is cytosolic, while the periplasmic form is rapidly
CC       degraded, mainly by the tail-specific protease. {ECO:0000255|HAMAP-
CC       Rule:MF_01332}.
CC   -!- SIMILARITY: Belongs to the SecM family. {ECO:0000255|HAMAP-
CC       Rule:MF_01332}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO67871.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAD01292.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL513382; CAD01292.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE014613; AAO67871.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000014336.1; NZ_WSUR01000009.1.
DR   AlphaFoldDB; Q8Z9G4; -.
DR   STRING; 220341.16501420; -.
DR   EnsemblBacteria; AAO67871; AAO67871; t0139.
DR   KEGG; stt:t0139; -.
DR   PATRIC; fig|90370.929.peg.4232; -.
DR   eggNOG; ENOG5031JGK; Bacteria.
DR   HOGENOM; CLU_108853_0_0_6; -.
DR   OMA; NYWQQHA; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR   HAMAP; MF_01332; SecM; 1.
DR   InterPro; IPR009502; SecM.
DR   Pfam; PF06558; SecM; 1.
DR   PIRSF; PIRSF004572; SecM; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Periplasm; Signal.
FT   SIGNAL          1..37
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01332"
FT   CHAIN           38..165
FT                   /note="Secretion monitor"
FT                   /id="PRO_0000031991"
SQ   SEQUENCE   165 AA;  18117 MW;  E81DAD332F1A366C CRC64;
     MSGILTRWRQ LGRRYFWPHL LLGMVAASFG LPALSNAAET NTPARTTAST ASKVNFSHLA
     LLEASNRRPN FTVDYWHQHA IRTVIRHLSF AMAPQTLPVA DAPSPLQAHH IALLNTLSAM
     LTQEGTPPAI VRRLSLAYFA PQTAFSIPAW ISQAQGIRAG PQRLS