ID   SECM_SODGM              Reviewed;         167 AA.
AC   Q2NVU4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Secretion monitor;
DE   Flags: Precursor;
GN   Name=secM; OrderedLocusNames=SG0456;
OS   Sodalis glossinidius (strain morsitans).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Bruguierivoracaceae; Sodalis.
OX   NCBI_TaxID=343509;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=morsitans;
RX   PubMed=16365377; DOI=10.1101/gr.4106106;
RA   Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M.,
RA   Aksoy S.;
RT   "Massive genome erosion and functional adaptations provide insights into
RT   the symbiotic lifestyle of Sodalis glossinidius in the tsetse host.";
RL   Genome Res. 16:149-156(2006).
CC   -!- FUNCTION: Regulates secA expression by translational coupling of the
CC       secM secA operon. Translational pausing at a specific Pro residue 5
CC       residues before the end of the protein may allow disruption of a mRNA
CC       repressor helix that normally suppresses secA translation initiation
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Periplasm
CC       {ECO:0000250}. Note=The active form is cytosolic, while the periplasmic
CC       form is rapidly degraded, mainly by the tail-specific protease.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SecM family. {ECO:0000305}.
CC   -!- CAUTION: This is very poor signal peptide prediction. {ECO:0000305}.
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DR   EMBL; AP008232; BAE73731.1; -; Genomic_DNA.
DR   RefSeq; WP_011410429.1; NZ_LN854557.1.
DR   AlphaFoldDB; Q2NVU4; -.
DR   STRING; 343509.SG0456; -.
DR   EnsemblBacteria; BAE73731; BAE73731; SG0456.
DR   KEGG; sgl:SG0456; -.
DR   eggNOG; ENOG5031JGK; Bacteria.
DR   HOGENOM; CLU_108853_0_0_6; -.
DR   OMA; NYWQQHA; -.
DR   OrthoDB; 1814644at2; -.
DR   BioCyc; SGLO343509:SGP1_RS04050-MON; -.
DR   Proteomes; UP000001932; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR   HAMAP; MF_01332; SecM; 1.
DR   InterPro; IPR009502; SecM.
DR   Pfam; PF06558; SecM; 1.
DR   PIRSF; PIRSF004572; SecM; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Periplasm; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..167
FT                   /note="Secretion monitor"
FT                   /id="PRO_0000314452"
SQ   SEQUENCE   167 AA;  18620 MW;  EE59E47BD19B8807 CRC64;
     MGILNRWRQI GRRYFWPHLL LGIVAAGFGV PLLPGGGQEM LYQADNCPSL SRQSAFQAGF
     SQLARLKDVP CRTTYAVDYW HQHAIRTVIR HLSIAWAPAP LPEAVAPLRV QHQVLLTTLG
     LLLNREARPP VLVRRLRSTG HVAFIDNRSG IRLTQQQGIR AGPHAAV