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SECM_YERPE
ID   SECM_YERPE              Reviewed;         177 AA.
AC   Q8ZIE1; Q0WJA4;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Secretion monitor {ECO:0000255|HAMAP-Rule:MF_01332};
DE   Flags: Precursor;
GN   Name=secM {ECO:0000255|HAMAP-Rule:MF_01332};
GN   OrderedLocusNames=YPO0563, y3618, YP_3621;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
RN   [4]
RP   DISCUSSION OF SEQUENCE.
RX   PubMed=10986266; DOI=10.1128/jb.182.19.5592-5595.2000;
RA   Sarker S., Rudd K.E., Oliver D.B.;
RT   "Revised translation start site for secM defines an atypical signal peptide
RT   that regulates Escherichia coli secA expression.";
RL   J. Bacteriol. 182:5592-5595(2000).
CC   -!- FUNCTION: Regulates secA expression by translational coupling of the
CC       secM secA operon. Translational pausing at a specific Pro residue 5
CC       residues before the end of the protein may allow disruption of a mRNA
CC       repressor helix that normally suppresses secA translation initiation.
CC       {ECO:0000255|HAMAP-Rule:MF_01332}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-
CC       Rule:MF_01332}. Periplasm {ECO:0000255|HAMAP-Rule:MF_01332}. Note=The
CC       active form is cytosolic, while the periplasmic form is rapidly
CC       degraded, mainly by the tail-specific protease. {ECO:0000255|HAMAP-
CC       Rule:MF_01332}.
CC   -!- SIMILARITY: Belongs to the SecM family. {ECO:0000255|HAMAP-
CC       Rule:MF_01332}.
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DR   EMBL; AL590842; CAL19242.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM87166.1; -; Genomic_DNA.
DR   EMBL; AE017042; AAS63769.1; -; Genomic_DNA.
DR   PIR; AH0069; AH0069.
DR   RefSeq; WP_002210427.1; NZ_WHLN01000070.1.
DR   RefSeq; YP_002345634.1; NC_003143.1.
DR   AlphaFoldDB; Q8ZIE1; -.
DR   STRING; 214092.YPO0563; -.
DR   PaxDb; Q8ZIE1; -.
DR   DNASU; 1148565; -.
DR   EnsemblBacteria; AAM87166; AAM87166; y3618.
DR   EnsemblBacteria; AAS63769; AAS63769; YP_3621.
DR   GeneID; 57974052; -.
DR   KEGG; ype:YPO0563; -.
DR   KEGG; ypk:y3618; -.
DR   KEGG; ypm:YP_3621; -.
DR   PATRIC; fig|214092.21.peg.816; -.
DR   eggNOG; ENOG5031JGK; Bacteria.
DR   HOGENOM; CLU_108853_0_0_6; -.
DR   OMA; NYWQQHA; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR   HAMAP; MF_01332; SecM; 1.
DR   InterPro; IPR009502; SecM.
DR   Pfam; PF06558; SecM; 1.
DR   PIRSF; PIRSF004572; SecM; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Periplasm; Reference proteome; Signal.
FT   SIGNAL          1..37
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01332"
FT   CHAIN           38..177
FT                   /note="Secretion monitor"
FT                   /id="PRO_0000031994"
SQ   SEQUENCE   177 AA;  19847 MW;  AD17C254C2F271D0 CRC64;
     MIGILNRWRQ FGRRYFWPHL LLGMVAASLG VPLNLSGVPD HAALANTSSS QSRQNHGTTN
     FNSLALLHDI HRRLSFSVDY WQQHALRTVI RHLSFALAPQ AAYARVQEVA ETERVAPSKI
     QQLALLDTLN ALLTHEFKPP AIIRYTEQVE RPVLSPYKPG LWLAQVQGIR AGPANLS
 
 
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