SECM_YERPE
ID SECM_YERPE Reviewed; 177 AA.
AC Q8ZIE1; Q0WJA4;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Secretion monitor {ECO:0000255|HAMAP-Rule:MF_01332};
DE Flags: Precursor;
GN Name=secM {ECO:0000255|HAMAP-Rule:MF_01332};
GN OrderedLocusNames=YPO0563, y3618, YP_3621;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
RN [4]
RP DISCUSSION OF SEQUENCE.
RX PubMed=10986266; DOI=10.1128/jb.182.19.5592-5595.2000;
RA Sarker S., Rudd K.E., Oliver D.B.;
RT "Revised translation start site for secM defines an atypical signal peptide
RT that regulates Escherichia coli secA expression.";
RL J. Bacteriol. 182:5592-5595(2000).
CC -!- FUNCTION: Regulates secA expression by translational coupling of the
CC secM secA operon. Translational pausing at a specific Pro residue 5
CC residues before the end of the protein may allow disruption of a mRNA
CC repressor helix that normally suppresses secA translation initiation.
CC {ECO:0000255|HAMAP-Rule:MF_01332}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-
CC Rule:MF_01332}. Periplasm {ECO:0000255|HAMAP-Rule:MF_01332}. Note=The
CC active form is cytosolic, while the periplasmic form is rapidly
CC degraded, mainly by the tail-specific protease. {ECO:0000255|HAMAP-
CC Rule:MF_01332}.
CC -!- SIMILARITY: Belongs to the SecM family. {ECO:0000255|HAMAP-
CC Rule:MF_01332}.
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DR EMBL; AL590842; CAL19242.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM87166.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS63769.1; -; Genomic_DNA.
DR PIR; AH0069; AH0069.
DR RefSeq; WP_002210427.1; NZ_WHLN01000070.1.
DR RefSeq; YP_002345634.1; NC_003143.1.
DR AlphaFoldDB; Q8ZIE1; -.
DR STRING; 214092.YPO0563; -.
DR PaxDb; Q8ZIE1; -.
DR DNASU; 1148565; -.
DR EnsemblBacteria; AAM87166; AAM87166; y3618.
DR EnsemblBacteria; AAS63769; AAS63769; YP_3621.
DR GeneID; 57974052; -.
DR KEGG; ype:YPO0563; -.
DR KEGG; ypk:y3618; -.
DR KEGG; ypm:YP_3621; -.
DR PATRIC; fig|214092.21.peg.816; -.
DR eggNOG; ENOG5031JGK; Bacteria.
DR HOGENOM; CLU_108853_0_0_6; -.
DR OMA; NYWQQHA; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR HAMAP; MF_01332; SecM; 1.
DR InterPro; IPR009502; SecM.
DR Pfam; PF06558; SecM; 1.
DR PIRSF; PIRSF004572; SecM; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Periplasm; Reference proteome; Signal.
FT SIGNAL 1..37
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01332"
FT CHAIN 38..177
FT /note="Secretion monitor"
FT /id="PRO_0000031994"
SQ SEQUENCE 177 AA; 19847 MW; AD17C254C2F271D0 CRC64;
MIGILNRWRQ FGRRYFWPHL LLGMVAASLG VPLNLSGVPD HAALANTSSS QSRQNHGTTN
FNSLALLHDI HRRLSFSVDY WQQHALRTVI RHLSFALAPQ AAYARVQEVA ETERVAPSKI
QQLALLDTLN ALLTHEFKPP AIIRYTEQVE RPVLSPYKPG LWLAQVQGIR AGPANLS