ID   SECR_CHICK              Reviewed;          27 AA.
AC   P01280;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Secretin {ECO:0000303|PubMed:7460928};
GN   Name=SCT {ECO:0000250|UniProtKB:P09683};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND AMIDATION AT MET-27.
RX   PubMed=7460928; DOI=10.1111/j.1432-1033.1980.tb07216.x;
RA   Nilsson A., Carlquist M., Joernvall H., Mutt V.;
RT   "Isolation and characterization of chicken secretin.";
RL   Eur. J. Biochem. 112:383-388(1980).
CC   -!- FUNCTION: Hormone involved in different processes, such as regulation
CC       of the pH of the duodenal content, food intake and water homeostasis.
CC       Exerts its biological effects by binding to secretin receptor (SCTR), a
CC       G-protein coupled receptor expressed in the basolateral domain of
CC       several cells. {ECO:0000250|UniProtKB:P11384}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7460928}.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   PIR; A01545; SECH.
DR   AlphaFoldDB; P01280; -.
DR   SMR; P01280; -.
DR   PaxDb; P01280; -.
DR   eggNOG; ENOG502R8F0; Eukaryota.
DR   HOGENOM; CLU_1677275_0_0_1; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0046659; F:digestive hormone activity; ISS:UniProtKB.
DR   GO; GO:0005179; F:hormone activity; ISS:UniProtKB.
DR   GO; GO:0009992; P:cellular water homeostasis; ISS:UniProtKB.
DR   GO; GO:0002024; P:diet induced thermogenesis; ISS:UniProtKB.
DR   GO; GO:0021766; P:hippocampus development; ISS:UniProtKB.
DR   GO; GO:0050996; P:positive regulation of lipid catabolic process; ISS:UniProtKB.
DR   GO; GO:0032098; P:regulation of appetite; ISS:UniProtKB.
DR   GO; GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.
DR   GO; GO:0031667; P:response to nutrient levels; ISS:UniProtKB.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   Pfam; PF00123; Hormone_2; 1.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Reference proteome;
KW   Secreted.
FT   PEPTIDE         1..27
FT                   /note="Secretin"
FT                   /evidence="ECO:0000269|PubMed:7460928"
FT                   /id="PRO_0000043938"
FT   MOD_RES         27
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:7460928"
SQ   SEQUENCE   27 AA;  3131 MW;  DA0AD71B6361BE7E CRC64;
     HSDGLFTSEY SKMRGNAQVQ KFIQNLM