ID   SECY2_STAAE             Reviewed;         403 AA.
AC   A6QKE2;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Accessory Sec system protein translocase subunit SecY2 {ECO:0000255|HAMAP-Rule:MF_01466};
GN   Name=secY2 {ECO:0000255|HAMAP-Rule:MF_01466}; OrderedLocusNames=NWMN_2552;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
CC   -!- FUNCTION: Part of the accessory SecA2/SecY2 system specifically
CC       required for export of possible cell wall proteins. The central subunit
CC       of a protein translocation channel. {ECO:0000255|HAMAP-Rule:MF_01466}.
CC   -!- SUBUNIT: Component of the accessory SecA2/SecY2 protein translocase
CC       complex required to export cell wall proteins. May form heterotrimers
CC       with SecE and SecG subunits. {ECO:0000255|HAMAP-Rule:MF_01466}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01466};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01466}.
CC   -!- SIMILARITY: Belongs to the SecY/SEC61-alpha family. SecY2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01466}.
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DR   EMBL; AP009351; BAF68824.1; -; Genomic_DNA.
DR   RefSeq; WP_000916119.1; NZ_CP023390.1.
DR   AlphaFoldDB; A6QKE2; -.
DR   SMR; A6QKE2; -.
DR   EnsemblBacteria; BAF68824; BAF68824; NWMN_2552.
DR   KEGG; sae:NWMN_2552; -.
DR   HOGENOM; CLU_030313_4_0_9; -.
DR   OMA; YSYLEIM; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0065002; P:intracellular protein transmembrane transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0006605; P:protein targeting; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3370.10; -; 1.
DR   HAMAP; MF_01466; SecY2; 1.
DR   InterPro; IPR002208; SecY/SEC61-alpha.
DR   InterPro; IPR014269; SecY2.
DR   InterPro; IPR023201; SecY_dom_sf.
DR   PANTHER; PTHR10906; PTHR10906; 1.
DR   Pfam; PF00344; SecY; 1.
DR   PIRSF; PIRSF004557; SecY; 1.
DR   SUPFAM; SSF103491; SSF103491; 1.
DR   TIGRFAMs; TIGR02920; acc_sec_Y2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Protein transport; Translocation; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..403
FT                   /note="Accessory Sec system protein translocase subunit
FT                   SecY2"
FT                   /id="PRO_0000414868"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
SQ   SEQUENCE   403 AA;  46885 MW;  0E2EF27001CC8327 CRC64;
     MLKLLQQYEY KIIYKRMLYT CFILFIYILG TNISIVSYND MQVKHESFFK IAISNMGGDV
     NTLNIFTLGL GPWLTSMIIL MLISYRNMDK YMKQTSLEKH YKERILTLIL SVIQSYFVIH
     EYVSKERVHQ DNIYLTILIL VTGTMLLVWL ADKNSRYGIA GPMPIVMVSI IKSMMHQKME
     YIDASHIVIA LLIILVIITL FILLFIELVE VRIPYIDLMN VSATNMKSYL SWKVNPAGSI
     TLMMSISAFV FLKSGIHFIL SMFNKSISDD MPMLTFDSPV GISVYLVIQM LLGYFLSRFL
     INTKQKSKDF LKSGNYFSGV KPGKDTERYL NYQARRVCWF GLALVTVIIG IPLYFTLFVP
     HLSTEIYFSV QLIVLVYISI NIAETIRTYL YFDKYKPFLN QYW