ID   SECY2_STRM6             Reviewed;         405 AA.
AC   D3HAJ5;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Accessory Sec system protein translocase subunit SecY2 {ECO:0000255|HAMAP-Rule:MF_01466};
GN   Name=secY2 {ECO:0000255|HAMAP-Rule:MF_01466}; OrderedLocusNames=smi_1653;
OS   Streptococcus mitis (strain B6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=365659;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B6;
RX   PubMed=20195536; DOI=10.1371/journal.pone.0009426;
RA   Denapaite D., Bruckner R., Nuhn M., Reichmann P., Henrich B., Maurer P.,
RA   Schahle Y., Selbmann P., Zimmermann W., Wambutt R., Hakenbeck R.;
RT   "The genome of Streptococcus mitis B6--what is a commensal?";
RL   PLoS ONE 5:E9426-E9426(2010).
CC   -!- FUNCTION: Part of the accessory SecA2/SecY2 system specifically
CC       required for export of possible cell wall proteins. The central subunit
CC       of a protein translocation channel. {ECO:0000255|HAMAP-Rule:MF_01466}.
CC   -!- SUBUNIT: Component of the accessory SecA2/SecY2 protein translocase
CC       complex required to export cell wall proteins. May form heterotrimers
CC       with SecE and SecG subunits. {ECO:0000255|HAMAP-Rule:MF_01466}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01466};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01466}.
CC   -!- SIMILARITY: Belongs to the SecY/SEC61-alpha family. SecY2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01466}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FN568063; CBJ22893.1; -; Genomic_DNA.
DR   RefSeq; WP_000161877.1; NC_013853.1.
DR   RefSeq; YP_003446755.1; NC_013853.1.
DR   AlphaFoldDB; D3HAJ5; -.
DR   SMR; D3HAJ5; -.
DR   STRING; 365659.smi_1653; -.
DR   EnsemblBacteria; CBJ22893; CBJ22893; smi_1653.
DR   KEGG; smb:smi_1653; -.
DR   PATRIC; fig|365659.3.peg.1673; -.
DR   eggNOG; COG0201; Bacteria.
DR   HOGENOM; CLU_030313_4_0_9; -.
DR   OMA; YSYLEIM; -.
DR   Proteomes; UP000008563; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0065002; P:intracellular protein transmembrane transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0006605; P:protein targeting; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3370.10; -; 1.
DR   HAMAP; MF_01466; SecY2; 1.
DR   InterPro; IPR002208; SecY/SEC61-alpha.
DR   InterPro; IPR014269; SecY2.
DR   InterPro; IPR023201; SecY_dom_sf.
DR   PANTHER; PTHR10906; PTHR10906; 1.
DR   Pfam; PF00344; SecY; 1.
DR   PIRSF; PIRSF004557; SecY; 1.
DR   SUPFAM; SSF103491; SSF103491; 1.
DR   TIGRFAMs; TIGR02920; acc_sec_Y2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Protein transport; Translocation; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..405
FT                   /note="Accessory Sec system protein translocase subunit
FT                   SecY2"
FT                   /id="PRO_0000414875"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
SQ   SEQUENCE   405 AA;  45168 MW;  DEEECCE7B444460E CRC64;
     MTKIYSSIAV KKGLYTLFLL FIYVLGSRIT LPFVDLNSKD FLGGSTAYLA FSAALTGGNL
     RSLSIFSVGL SPWMSAMILW QMFSYSKKLG LSSTAIEIQD RRKMYLTLLI AVIQSLAVSL
     SLPVQSSYSA ILVVLMNTLL LIAGTFFLVW LSDLNASMGI GGSIVILLSS IVLNIPQDVI
     ETFQTVHIPT GIIVLLALLT LVFSYLLAIM YRARYLVPVN KIGLHNRFKR YSYLEIMLNP
     AGGMPYMYVM SFLSVPAYLF ILLGFIFPNH AGLAALSKEF MVGKPLWVYV YISVLFLFSI
     IFAFVTMNGE EIADRMKKSG EYIYGIYPGE DTSRFINGLV LRFSVIGGLF NVIMAGGPML
     FVLFDEKLLR LAMIPGLFMM FGGMIFTIRD EVKALRLNET YKPLI