ID   SECY2_STRSV             Reviewed;         407 AA.
AC   A3CM55;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Accessory Sec system protein translocase subunit SecY2 {ECO:0000255|HAMAP-Rule:MF_01466};
GN   Name=secY2 {ECO:0000255|HAMAP-Rule:MF_01466}; OrderedLocusNames=SSA_0832;
OS   Streptococcus sanguinis (strain SK36).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=388919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK36;
RX   PubMed=17277061; DOI=10.1128/jb.01808-06;
RA   Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P.,
RA   Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D.,
RA   Paik S., Peterson D.L., Macrina F.L., Buck G.A.;
RT   "Genome of the opportunistic pathogen Streptococcus sanguinis.";
RL   J. Bacteriol. 189:3166-3175(2007).
CC   -!- FUNCTION: Part of the accessory SecA2/SecY2 system specifically
CC       required for export of possible cell wall proteins. The central subunit
CC       of a protein translocation channel. {ECO:0000255|HAMAP-Rule:MF_01466}.
CC   -!- SUBUNIT: Component of the accessory SecA2/SecY2 protein translocase
CC       complex required to export cell wall proteins. May form heterotrimers
CC       with SecE and SecG subunits. {ECO:0000255|HAMAP-Rule:MF_01466}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01466};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01466}.
CC   -!- SIMILARITY: Belongs to the SecY/SEC61-alpha family. SecY2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01466}.
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DR   EMBL; CP000387; ABN44260.1; -; Genomic_DNA.
DR   RefSeq; WP_011836742.1; NC_009009.1.
DR   RefSeq; YP_001034810.1; NC_009009.1.
DR   AlphaFoldDB; A3CM55; -.
DR   STRING; 388919.SSA_0832; -.
DR   EnsemblBacteria; ABN44260; ABN44260; SSA_0832.
DR   KEGG; ssa:SSA_0832; -.
DR   PATRIC; fig|388919.9.peg.795; -.
DR   eggNOG; COG0201; Bacteria.
DR   HOGENOM; CLU_030313_4_0_9; -.
DR   OMA; YSYLEIM; -.
DR   OrthoDB; 1567535at2; -.
DR   Proteomes; UP000002148; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0065002; P:intracellular protein transmembrane transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0006605; P:protein targeting; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3370.10; -; 1.
DR   HAMAP; MF_01466; SecY2; 1.
DR   InterPro; IPR002208; SecY/SEC61-alpha.
DR   InterPro; IPR014269; SecY2.
DR   InterPro; IPR023201; SecY_dom_sf.
DR   PANTHER; PTHR10906; PTHR10906; 1.
DR   Pfam; PF00344; SecY; 1.
DR   PIRSF; PIRSF004557; SecY; 1.
DR   SUPFAM; SSF103491; SSF103491; 1.
DR   TIGRFAMs; TIGR02920; acc_sec_Y2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Protein transport; Reference proteome;
KW   Translocation; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..407
FT                   /note="Accessory Sec system protein translocase subunit
FT                   SecY2"
FT                   /id="PRO_0000414212"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01466"
SQ   SEQUENCE   407 AA;  46130 MW;  FEF60038BC10F7FD CRC64;
     MKSFFKPVII KKFLWTLFFL FIYVLGTKLT LPFVDMSKAA AMDGTSTTLN YATALMGGNL
     RSMSLFSVGL SPWMSSMLIW QMFAVSKRLG LSKLPLEVQE RRRMLLTLVI ALIQSVALVL
     NLPLQEAAGV DMTTIMVLDT LVLMAGTYFL IWLTDLNAAM GLGGSIMIVM ASMIAYIPQD
     IWNSIQELKI SSLWLALMLV FSLVFLYLAV TVERSKYRIP VNKINIHNRF KKYSYLDIRL
     NPAGGMPIMY AMTLVSIPQY FLLIIHFLQP ENQLIEQWIE ALSMGSPAWF ILYLLTIFIL
     ALAFAFINIS GDQIAERMQK SGEYIENVYP GGATRRYING LVTYFALVGA FYLILISGLP
     MMVVLVDIRY LRLSMIPGIF MIFIGMVFSI KDEVEALTLN DRYRSLL