ID   SED5_SCHPO              Reviewed;         309 AA.
AC   O13644;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=Integral membrane protein sed5;
GN   Name=sed5; ORFNames=pi051, SPBC8D2.14c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=10620777;
RX   DOI=10.1002/(sici)1097-0061(20000115)16:1<71::aid-yea505>3.0.co;2-5;
RA   Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K.,
RA   Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y.,
RA   Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., Yanagida M.;
RT   "A 38 kb segment containing the cdc2 gene from the left arm of fission
RT   yeast chromosome II: sequence analysis and characterization of the genomic
RT   DNA and cDNAs encoded on the segment.";
RL   Yeast 16:71-80(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Required for vesicular transport between the endoplasmic
CC       reticulum and the Golgi complex. Acts as a target organelle soluble NSF
CC       attachment protein receptor (t-SNARE) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC       membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000305};
CC       Single-pass type IV membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
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DR   EMBL; AB004538; BAA21432.1; -; Genomic_DNA.
DR   EMBL; CU329671; CAA17829.1; -; Genomic_DNA.
DR   PIR; T40759; T40759.
DR   RefSeq; NP_595576.1; NM_001021471.2.
DR   AlphaFoldDB; O13644; -.
DR   SMR; O13644; -.
DR   BioGRID; 277777; 1.
DR   STRING; 4896.SPBC8D2.14c.1; -.
DR   MaxQB; O13644; -.
DR   PaxDb; O13644; -.
DR   EnsemblFungi; SPBC8D2.14c.1; SPBC8D2.14c.1:pep; SPBC8D2.14c.
DR   GeneID; 2541263; -.
DR   KEGG; spo:SPBC8D2.14c; -.
DR   PomBase; SPBC8D2.14c; sed5.
DR   VEuPathDB; FungiDB:SPBC8D2.14c; -.
DR   eggNOG; KOG0812; Eukaryota.
DR   HOGENOM; CLU_044998_0_1_1; -.
DR   InParanoid; O13644; -.
DR   OMA; RGITGTM; -.
DR   PhylomeDB; O13644; -.
DR   Reactome; R-SPO-204005; COPII-mediated vesicle transport.
DR   Reactome; R-SPO-5694530; Cargo concentration in the ER.
DR   Reactome; R-SPO-6807878; COPI-mediated anterograde transport.
DR   Reactome; R-SPO-6811438; Intra-Golgi traffic.
DR   Reactome; R-SPO-9013106; RHOC GTPase cycle.
DR   Reactome; R-SPO-9609523; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
DR   PRO; PR:O13644; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005801; C:cis-Golgi network; ISS:PomBase.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0005484; F:SNAP receptor activity; ISS:PomBase.
DR   GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0048278; P:vesicle docking; IBA:GO_Central.
DR   GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR   InterPro; IPR010989; SNARE.
DR   InterPro; IPR045242; Syntaxin.
DR   InterPro; IPR021538; Syntaxin-5_N.
DR   InterPro; IPR000727; T_SNARE_dom.
DR   PANTHER; PTHR19957; PTHR19957; 1.
DR   Pfam; PF05739; SNARE; 1.
DR   Pfam; PF11416; Syntaxin-5_N; 1.
DR   SMART; SM00397; t_SNARE; 1.
DR   SUPFAM; SSF47661; SSF47661; 1.
DR   PROSITE; PS50192; T_SNARE; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Golgi apparatus; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..309
FT                   /note="Integral membrane protein sed5"
FT                   /id="PRO_0000210272"
FT   TOPO_DOM        1..288
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..308
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        309
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          218..280
FT                   /note="t-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT   COILED          37..66
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   309 AA;  34890 MW;  545BD2B0E4ADD7E8 CRC64;
     MSFQDRTAEF QACVTKTRSR LRTTTANQAV GGPDQTKHQK SEFTRIAQKI ANQINQTGEK
     LQKLSQLAKR KTLFDDRPVE IQELTFQIKQ SLSSLNSDIA SLQQVVKGNR NKPAQMNQHS
     ENVVVSLQNS LANTSMTFKD ILEIRTQNMK ASQNRTEKFV ASSSMNANPL INSGNSISPF
     ADYNDPKPEA NEDYLSLNLG DGANTRYEQM ALLESQTDTY SQQRMSSIQN IESTITELGG
     IFSQLAQMVS EQRETVQRID MHTDDIVSNI GSAQREIVKF YERMSSNRAL LFKIFGIVII
     FFLLWVLVT