ID   SEF1_ASHGO              Reviewed;        1051 AA.
AC   Q74Z37;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Putative transcription factor SEF1;
DE   AltName: Full=Suppressor protein SEF1 homolog;
GN   Name=SEF1; OrderedLocusNames=AGR369W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Putative transcription factor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016820; AAS54859.1; -; Genomic_DNA.
DR   RefSeq; NP_987035.1; NM_212097.1.
DR   AlphaFoldDB; Q74Z37; -.
DR   STRING; 33169.AAS54859; -.
DR   EnsemblFungi; AAS54859; AAS54859; AGOS_AGR369W.
DR   GeneID; 4623338; -.
DR   KEGG; ago:AGOS_AGR369W; -.
DR   eggNOG; ENOG502QR4T; Eukaryota.
DR   HOGENOM; CLU_010150_0_0_1; -.
DR   InParanoid; Q74Z37; -.
DR   OMA; LVWCVHE; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..1051
FT                   /note="Putative transcription factor SEF1"
FT                   /id="PRO_0000114975"
FT   DNA_BIND        92..122
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          67..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          206..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          738..759
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          927..968
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..53
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1051 AA;  115375 MW;  FE6CAB9ECAAAA6B7 CRC64;
     MSTDVSERGA EAGSSSGLLS SPCVGDGSDS AQMKKRNTET AGMKARKKLR SEESGLSTLV
     SIASFGGQAS PDRSKVSKQQ NGASGHRPVT SCTHCRQHKI KCNASENFPS SCSRCERMGL
     QCEIDPQFRP KKGSQLQNLK NEIEELKTKL EFLLRSEGIL SSAMRNSDLG RQILQAIKLQ
     DSPQQQTGIS VQTYLASEPE LLKSESSVKS SVNTPSGSYS ASAVDVSRAK TNSVPPLLND
     SAPANSNRES LPPVLQMALK YHNSSHNTPI DTPSSHTTPM LSPEVKKPVV ATTNAMPLLP
     SPYANIDEFV LGDVHIPIDK AKELHHIFVK KYLPYFPIMT TDSVTELYSQ SQLLFWTIML
     TACLSDPEPT LYNSLASLIK QLAIETCWIR TPRSTHISQA LLILCNWPLP NQKVLDDCSY
     RFVGLAKSLS FQLGLHRGEF MSEFTRTQTL MPDAEKWRTR TWLGIFFAEQ CWSSILGLPS
     TSQTDYFIEQ ARRGKFDLPV RFHRLLCLAH FQASLSNIMG SSVESPDGLM DAKERGSSLA
     ALERELARLH SELKFDSDPV VEMYYLYAKL MIYCFAFLPE TPKADQTQYV TEAYLAATRI
     ITLLTKTLED TQLIELPIYV RQSVTYAALI LFKLHLTPYL PEKYVDSARQ SIVTVHRLYR
     NQLTAWATGV ENDISRTASV LEKLNFVLIT YPEIFVEEDG IISRMRSHLT GTLFYDLIYC
     VHEARRRQVD SEYNEMLEKN RKEQPVHTAA TGSQDTEKRA PKRRLFPLPF YNQISKEDFE
     TITQTTPGGT TVTTLVPTKN AILQAKKLQR SQGGQKGEPI RSINGIPLAM LDATGSVNGA
     LVGDNLNSSV PQAAVAASAP PEPAAVAATV PPEPAPAPGG QSYPLFQPLY VQPAANVPMQ
     RSASASVAEA LPFRRPGMPK ITSESIASGN PNSLFGNDGS PFPAIAQKSA KPAPPAKPDG
     QPAKQPAPYP NLNVFLGANA SARMASYSSL MDAADPLAPD PDRAPLAAPG PLAHISELDS
     FFLQQSAGWI EGSSSNDDFL GWYDINMAPE F