ID   SEF1_KLULA              Reviewed;        1119 AA.
AC   P87164; B4UN78; Q6CMG9;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 3.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Putative transcription factor SEF1;
DE   AltName: Full=Suppressor protein SEF1;
GN   Name=SEF1; OrderedLocusNames=KLLA0E20307g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=9483797;
RX   DOI=10.1002/(sici)1097-0061(19980115)14:1<77::aid-yea201>3.0.co;2-p;
RA   Groom K.R., Heyman H.C., Steffen M.C., Hawkins L., Martin N.C.;
RT   "Kluyveromyces lactis SEF1 and its Saccharomyces cerevisiae homologue
RT   bypass the unknown essential function, but not the mitochondrial RNase P
RT   function, of the S. cerevisiae RPM2 gene.";
RL   Yeast 14:77-87(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Putative transcription factor. Suppresses the lethal
CC       phenotype of RPM2 deletion. {ECO:0000269|PubMed:9483797}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC39353.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; U92898; AAC39353.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; CR382125; CAR56749.1; -; Genomic_DNA.
DR   PIR; T18307; T18307.
DR   RefSeq; XP_002999411.1; XM_002999365.1.
DR   AlphaFoldDB; P87164; -.
DR   STRING; 28985.XP_002999411.1; -.
DR   PRIDE; P87164; -.
DR   EnsemblFungi; CAR56749; CAR56749; KLLA0_E20307g.
DR   GeneID; 9487299; -.
DR   KEGG; kla:KLLA0_E20307g; -.
DR   eggNOG; ENOG502QR4T; Eukaryota.
DR   HOGENOM; CLU_010150_0_0_1; -.
DR   InParanoid; P87164; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   4: Predicted;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..1119
FT                   /note="Putative transcription factor SEF1"
FT                   /id="PRO_0000114976"
FT   DNA_BIND        118..148
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          86..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          236..290
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          306..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          894..913
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          926..962
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          994..1018
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..70
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..287
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        448
FT                   /note="A -> R (in Ref. 1; AAC39353)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        466
FT                   /note="C -> S (in Ref. 1; AAC39353)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        789
FT                   /note="R -> E (in Ref. 1; AAC39353)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1095
FT                   /note="A -> S (in Ref. 1; AAC39353)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1109..1119
FT                   /note="GWFDMNMAPEF -> DGSR (in Ref. 1; AAC39353)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1119 AA;  123242 MW;  CD47B98B8CB7BAF0 CRC64;
     MGDPVSSKRK SSVSDAVSTS KRQHQQVKVE DVNVPLSSRE HSPGPQLHTQ QSYYGNGTDG
     ASESALTQSR NNNGATSVVA ISDATQNGED SSNISNNSNA VSKGKAVVNA GHRPVTSCTH
     CRQHKIKCNA SEKFPAPCSR CERMGLHCEI DPQFRPKKGS QLQSLRNDVD ELKVKIEYLT
     RNESLIAKAL KQSNIGQNLL QAIKSVDFSY RVAGPTQGQV AKNKISVQTY LTNEPQLLQD
     SQTTTTNPTT SSNSKVVTPT GSDHSPASHN GGSLSSGKPQ LLNDSVPANT KDRLPPVLQI
     ALKRLSQQIS SSSPQNSSPT TTGHSPANDL SSSKQHVVAT TNAMPLLPSP HANIDEFVLG
     DVHISIEKAT ELHNIFVARF LPYFPIMQSN SATELYSQSQ LLFWTVILTA SLSDPEPTLY
     NKLSSLIKQL AIETCWIRTP RSTHISQALL ILCNWPLPNQ KVLDDCSYRF VGLAKSLSFQ
     LGLHRGKFMT EFTRTQTSLP EAEKWRTRTW LGIFFAEQLW ASILGLPPTS QTDYLIEKAR
     LGDDGELPPI LRKLICLANF QGKLCNVMGT SVVSPDGLMD ARERAGSLAI LERELERLDV
     KLKFQEDAAV EIYFLYIKLM ICCFAFLPET PTEDQTKYVT EAYLCATKII TLLTKLLETQ
     QLIELPIYIR HSATYSALIL FKLYLTPLLL DKYVDSARQS IVTVHRLYRN QLTAWAASVE
     NDISRTASVL EKLNFVLVTH PEVFIEEEGI ISRMRSHLTG TLFYDLVWCV HEARRRQMDP
     NYDAEAAKRN KEKWFKNRRK LYPLPFYNQI SKEDFETITQ TTPGGTTVTT LVPTKSAIKQ
     AKQLAQSQGD QNGPVTHING IPLSMLDETG SVNIEGLLAN ANLNLSNEHS TVLASSSSTA
     TRLNADNPTT DTNKFNVQTV FTHNIKKSSK SSDTPTNKPK FNSTSSIPTA TPTSEQRAAH
     NTKTSASILT GDPNSLFSMN NSLQANIQLN KTLSADSNGT SNNNIPNSTA PLNTPDTNSF
     NSLTRSPDAP SYGNMNVFYN AANQGTNMNT LYSQSVPNAP QGISAPLSAQ PVNVTNIPNG
     NVNSELDDFF LRQSAGWIEG NSSNDDFLGW FDMNMAPEF