ID   SEH1A_XENLA             Reviewed;         360 AA.
AC   Q4FZW5;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Nucleoporin SEH1-A {ECO:0000305};
DE   AltName: Full=GATOR complex protein SEH1-A {ECO:0000305};
DE   AltName: Full=Nup107-160 subcomplex subunit seh1-A;
GN   Name=seh1l-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Nup107-160 subcomplex of the nuclear pore
CC       complex (NPC). The Nup107-160 subcomplex is required for the assembly
CC       of a functional NPC. The Nup107-160 subcomplex is also required for
CC       normal kinetochore microtubule attachment, mitotic progression and
CC       chromosome segregation. This subunit plays a role in recruitment of the
CC       Nup107-160 subcomplex to the kinetochore.
CC       {ECO:0000250|UniProtKB:Q96EE3}.
CC   -!- FUNCTION: As a component of the GATOR complex may function in the amino
CC       acid-sensing branch of the TORC1 signaling pathway.
CC       {ECO:0000250|UniProtKB:Q96EE3}.
CC   -!- SUBUNIT: Component of the Nup107-160 subcomplex of the nuclear pore
CC       complex (NPC). Probably part of the GATOR complex.
CC       {ECO:0000250|UniProtKB:Q96EE3}.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC       {ECO:0000250|UniProtKB:Q96EE3}. Nucleus, nuclear pore complex
CC       {ECO:0000250|UniProtKB:Q96EE3}. Lysosome membrane
CC       {ECO:0000250|UniProtKB:Q96EE3}.
CC   -!- SIMILARITY: Belongs to the WD repeat SEC13 family. {ECO:0000305}.
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DR   EMBL; BC099027; AAH99027.1; -; mRNA.
DR   RefSeq; NP_001089593.1; NM_001096124.1.
DR   PDB; 6LK8; EM; 5.50 A; D/d=1-322.
DR   PDB; 7VCI; EM; 8.10 A; C/L=1-360.
DR   PDB; 7VOP; EM; 8.70 A; C/L=1-360.
DR   PDBsum; 6LK8; -.
DR   PDBsum; 7VCI; -.
DR   PDBsum; 7VOP; -.
DR   AlphaFoldDB; Q4FZW5; -.
DR   SMR; Q4FZW5; -.
DR   DNASU; 734650; -.
DR   GeneID; 734650; -.
DR   KEGG; xla:734650; -.
DR   CTD; 734650; -.
DR   Xenbase; XB-GENE-1015667; seh1l.L.
DR   OrthoDB; 944756at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 734650; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0031080; C:nuclear pore outer ring; ISS:UniProtKB.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007080; P:mitotic metaphase plate congression; ISS:UniProtKB.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0006999; P:nuclear pore organization; ISS:UniProtKB.
DR   GO; GO:1904263; P:positive regulation of TORC1 signaling; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR037597; Nucleoporin_Seh1.
DR   InterPro; IPR037363; Sec13/Seh1_fam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR11024; PTHR11024; 1.
DR   PANTHER; PTHR11024:SF3; PTHR11024:SF3; 1.
DR   Pfam; PF00400; WD40; 2.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   1: Evidence at protein level;
KW   3D-structure; Cell cycle; Cell division; Centromere; Chromosome;
KW   Chromosome partition; Kinetochore; Lysosome; Membrane; Mitosis;
KW   mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW   Reference proteome; Repeat; Translocation; Transport; WD repeat.
FT   CHAIN           1..360
FT                   /note="Nucleoporin SEH1-A"
FT                   /id="PRO_0000373808"
FT   REPEAT          10..49
FT                   /note="WD 1"
FT   REPEAT          55..96
FT                   /note="WD 2"
FT   REPEAT          111..152
FT                   /note="WD 3"
FT   REPEAT          160..210
FT                   /note="WD 4"
FT   REPEAT          217..258
FT                   /note="WD 5"
FT   REPEAT          276..315
FT                   /note="WD 6"
SQ   SEQUENCE   360 AA;  39726 MW;  82C535A5066E94A2 CRC64;
     MFVARSIAAD HKDLIHDVSF DFHGRRMATC SSDQSVKVWD KSENGNWHCT ASWKTHSGSV
     WRVTWAHPEF GQVLASCSFD RTAAVWEEIV GESNDKLRGQ SHWVKRTTLV DSRTSVTDVK
     FAPKHMGLML ATCSADGVVR IYEAPDVMNL SQWSLQHEIS CKLSCSCISW NPSSSRAHSP
     MIAVGSDDSS PNIMGKVQIY EYNENTRKYA KAETLMSVSD PVHDIAFAPN LGRSFHILAV
     ATKDVRIFTM KPLRKELSSS GGVTKFEIHT VAQFDNHNSQ VWRVSWNITG TVLASSGDDG
     TVRLWKANYM DNWKCIGVLK GDGNPVGNSY QGFFGSSVGS AGQSLQNSVN GTPSSGRKHS