SEH1_CAEBR
ID SEH1_CAEBR Reviewed; 366 AA.
AC A8WVD2;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Nucleoporin SEH1 {ECO:0000250|UniProtKB:O45933};
DE AltName: Full=GATOR complex protein SEH1 {ECO:0000305};
DE AltName: Full=Nuclear pore complex protein 18 {ECO:0000250|UniProtKB:O45933, ECO:0000312|EMBL:CAP24443.1};
DE AltName: Full=SEC13-like protein {ECO:0000250|UniProtKB:O45933};
GN Name=npp-18 {ECO:0000312|WormBase:CBG03573}; ORFNames=CBG03573;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1] {ECO:0000312|EMBL:CAP24443.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000312|EMBL:CAP24443.1};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Probable component of the nuclear pore complex (NPC) which is
CC involved in the trafficking of macromolecules between the cytoplasm and
CC nucleus. {ECO:0000250|UniProtKB:O45933}.
CC -!- FUNCTION: As a component of the GATOR complex may function in the amino
CC acid-sensing branch of the TORC1 signaling pathway.
CC {ECO:0000250|UniProtKB:P55735}.
CC -!- SUBUNIT: Component of the nuclear pore complex (NPC). Probably part of
CC the GATOR complex. {ECO:0000250|UniProtKB:Q96EE3}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:Q96EE3}. Lysosome membrane
CC {ECO:0000250|UniProtKB:Q96EE3}.
CC -!- SIMILARITY: Belongs to the WD repeat SEC13 family. {ECO:0000255}.
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DR EMBL; HE601339; CAP24443.1; -; Genomic_DNA.
DR RefSeq; XP_002647052.1; XM_002647006.1.
DR AlphaFoldDB; A8WVD2; -.
DR SMR; A8WVD2; -.
DR STRING; 6238.CBG03573; -.
DR EnsemblMetazoa; CBG03573.1; CBG03573.1; WBGene00026412.
DR GeneID; 8589051; -.
DR KEGG; cbr:CBG_03573; -.
DR CTD; 8589051; -.
DR WormBase; CBG03573; CBP14769; WBGene00026412; Cbr-npp-18.
DR eggNOG; KOG2445; Eukaryota.
DR HOGENOM; CLU_032441_1_1_1; -.
DR InParanoid; A8WVD2; -.
DR OMA; ESQWIRR; -.
DR OrthoDB; 944756at2759; -.
DR Proteomes; UP000008549; Chromosome III.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031080; C:nuclear pore outer ring; IBA:GO_Central.
DR GO; GO:0035859; C:Seh1-associated complex; IBA:GO_Central.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR037597; Nucleoporin_Seh1.
DR InterPro; IPR037363; Sec13/Seh1_fam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR11024; PTHR11024; 1.
DR PANTHER; PTHR11024:SF3; PTHR11024:SF3; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Lysosome; Membrane; mRNA transport; Nuclear pore complex; Nucleus;
KW Protein transport; Reference proteome; Repeat; Translocation; Transport;
KW WD repeat.
FT CHAIN 1..366
FT /note="Nucleoporin SEH1"
FT /id="PRO_0000405804"
FT REPEAT 18..57
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 63..104
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 111..152
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 161..209
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 226..267
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 290..329
FT /note="WD 6"
FT /evidence="ECO:0000255"
SQ SEQUENCE 366 AA; 41885 MW; FDCF92350AD7776D CRC64;
MSADKSPYQI EPYKTVGAHR DLIHCVSFDP HGRRMATCAS DMTMAIWDRQ PDGNWRRSAH
WKCHGGAVWR VIWAHPEFGQ IVASCSYDRT IVIWEEQIVR TEKDLKCKES QWIRRTIISD
NRSDVTDICF SPRHLGLSLA SCNVLGAVRI YEAPDVVDAS RWNLIHELQA FHTRCGCVTW
SLSRMHRPLI AVGSDEKKAG GKERVVIYEN IDGLRKWQRI HSLVFDMPCP ITDLKFSPIS
MVDSHQLAIA SGDVHVFNIK VPRTAILEED GVDNPIHLAD YSFQRVALLG DQRKAWRIRY
NLIGSVITST SLDGTLRSWK SLFVNQWVKL SEMNVDDYVP TADEVHKIVE AKTTERLPSQ
LDKVYF
