ID   SEH1_OSMMO              Reviewed;         364 AA.
AC   C1BK83;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Nucleoporin SEH1 {ECO:0000305};
DE   AltName: Full=GATOR complex protein SEH1 {ECO:0000305};
DE   AltName: Full=Nup107-160 subcomplex subunit seh1;
GN   Name=seh1l;
OS   Osmerus mordax (Rainbow smelt) (Atherina mordax).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Stomiati; Osmeriformes; Osmeridae;
OC   Osmerus.
OX   NCBI_TaxID=8014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RA   von Schalburg K., Leong J., Cooper G.A., Davidson W.S., Koop B.F.;
RT   "Osmerus mordax full-length cDNAs.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Nup107-160 subcomplex of the nuclear pore
CC       complex (NPC). The Nup107-160 subcomplex is required for the assembly
CC       of a functional NPC. The Nup107-160 subcomplex is also required for
CC       normal kinetochore microtubule attachment, mitotic progression and
CC       chromosome segregation. This subunit plays a role in recruitment of the
CC       Nup107-160 subcomplex to the kinetochore.
CC       {ECO:0000250|UniProtKB:Q96EE3}.
CC   -!- FUNCTION: As a component of the GATOR complex may function in the amino
CC       acid-sensing branch of the TORC1 signaling pathway.
CC       {ECO:0000250|UniProtKB:Q96EE3}.
CC   -!- SUBUNIT: Component of the Nup107-160 subcomplex of the nuclear pore
CC       complex (NPC). Probably part of the GATOR complex.
CC       {ECO:0000250|UniProtKB:Q96EE3}.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC       {ECO:0000250|UniProtKB:Q96EE3}. Nucleus, nuclear pore complex
CC       {ECO:0000250|UniProtKB:Q96EE3}. Lysosome membrane
CC       {ECO:0000250|UniProtKB:Q96EE3}.
CC   -!- SIMILARITY: Belongs to the WD repeat SEC13 family. {ECO:0000305}.
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DR   EMBL; BT075012; ACO09436.1; -; mRNA.
DR   AlphaFoldDB; C1BK83; -.
DR   SMR; C1BK83; -.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0031080; C:nuclear pore outer ring; ISS:UniProtKB.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007080; P:mitotic metaphase plate congression; ISS:UniProtKB.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0006999; P:nuclear pore organization; ISS:UniProtKB.
DR   GO; GO:1904263; P:positive regulation of TORC1 signaling; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR037597; Nucleoporin_Seh1.
DR   InterPro; IPR037363; Sec13/Seh1_fam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR11024; PTHR11024; 1.
DR   PANTHER; PTHR11024:SF3; PTHR11024:SF3; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW   Kinetochore; Lysosome; Membrane; Mitosis; mRNA transport;
KW   Nuclear pore complex; Nucleus; Protein transport; Repeat; Translocation;
KW   Transport; WD repeat.
FT   CHAIN           1..364
FT                   /note="Nucleoporin SEH1"
FT                   /id="PRO_0000383046"
FT   REPEAT          10..49
FT                   /note="WD 1"
FT   REPEAT          55..96
FT                   /note="WD 2"
FT   REPEAT          111..152
FT                   /note="WD 3"
FT   REPEAT          160..210
FT                   /note="WD 4"
FT   REPEAT          217..258
FT                   /note="WD 5"
FT   REPEAT          275..314
FT                   /note="WD 6"
FT   REGION          326..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   364 AA;  39844 MW;  A87211BFF2B8111E CRC64;
     MFVARSIAAD HKDLIHDVSY DFHGRRMATC SSDQSVKVWD KSDNGEWNCT ASWKTHSGSV
     WRVTWAHPEF GQVLASCSFD RTAAVWEEIV GESNDKQRGL SHWIKRTTLV DSRTSVTDVK
     FAPKHMGLML TTCSADGVVR IYEAPDVMNL SQWSLQHEIS CKLSCSCISW NPSSSRAHSP
     MIAVGSDDSN TAYSGKVQIY EYVENTRKYA KVETLMTVTD PVHDIAFAPN LGRSFHVLAI
     ATKDVRIFKL IPMRKESSSS GPTKLEVQLQ AQFDGHNSQV WRVSWNITST LLASSGDDGC
     VRLWKANYMD NWKCTGILRG DGSPVNGAAG QAGTPGAAGT PGGPASQNAL QAVAGRKKAQ
     LMPG