SEH1_XENTR
ID SEH1_XENTR Reviewed; 360 AA.
AC Q5U4Y8;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Nucleoporin SEH1 {ECO:0000305};
DE AltName: Full=GATOR complex protein SEH1 {ECO:0000305};
DE AltName: Full=Nup107-160 subcomplex subunit seh1;
GN Name=seh1l; ORFNames=TGas096l04.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Nup107-160 subcomplex of the nuclear pore
CC complex (NPC). The Nup107-160 subcomplex is required for the assembly
CC of a functional NPC. The Nup107-160 subcomplex is also required for
CC normal kinetochore microtubule attachment, mitotic progression and
CC chromosome segregation. This subunit plays a role in recruitment of the
CC Nup107-160 subcomplex to the kinetochore.
CC {ECO:0000250|UniProtKB:Q96EE3}.
CC -!- FUNCTION: As a component of the GATOR complex may function in the amino
CC acid-sensing branch of the TORC1 signaling pathway.
CC {ECO:0000250|UniProtKB:Q96EE3}.
CC -!- SUBUNIT: Component of the Nup107-160 subcomplex of the nuclear pore
CC complex (NPC). Probably part of the GATOR complex.
CC {ECO:0000250|UniProtKB:Q96EE3}.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000250|UniProtKB:Q96EE3}. Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:Q96EE3}. Lysosome membrane
CC {ECO:0000250|UniProtKB:Q96EE3}.
CC -!- SIMILARITY: Belongs to the WD repeat SEC13 family. {ECO:0000305}.
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DR EMBL; CR855721; CAJ82514.1; -; mRNA.
DR EMBL; BC084902; AAH84902.1; -; mRNA.
DR RefSeq; NP_001011152.1; NM_001011152.2.
DR AlphaFoldDB; Q5U4Y8; -.
DR SMR; Q5U4Y8; -.
DR STRING; 8364.ENSXETP00000055056; -.
DR PaxDb; Q5U4Y8; -.
DR DNASU; 496570; -.
DR Ensembl; ENSXETT00000055056; ENSXETP00000055056; ENSXETG00000019668.
DR GeneID; 496570; -.
DR KEGG; xtr:496570; -.
DR CTD; 81929; -.
DR Xenbase; XB-GENE-1015661; seh1l.
DR eggNOG; KOG2445; Eukaryota.
DR HOGENOM; CLU_032441_1_2_1; -.
DR InParanoid; Q5U4Y8; -.
DR OMA; NAPTRRW; -.
DR OrthoDB; 944756at2759; -.
DR TreeFam; TF105924; -.
DR Reactome; R-XTR-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR Reactome; R-XTR-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-XTR-159230; Transport of the SLBP Dependant Mature mRNA.
DR Reactome; R-XTR-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-XTR-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-XTR-2467813; Separation of Sister Chromatids.
DR Reactome; R-XTR-2500257; Resolution of Sister Chromatid Cohesion.
DR Reactome; R-XTR-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-XTR-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR Reactome; R-XTR-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-XTR-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-XTR-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-XTR-4570464; SUMOylation of RNA binding proteins.
DR Reactome; R-XTR-4615885; SUMOylation of DNA replication proteins.
DR Reactome; R-XTR-5578749; Transcriptional regulation by small RNAs.
DR Reactome; R-XTR-5663220; RHO GTPases Activate Formins.
DR Reactome; R-XTR-9639288; Amino acids regulate mTORC1.
DR Reactome; R-XTR-9648025; EML4 and NUDC in mitotic spindle formation.
DR Proteomes; UP000008143; Chromosome 6.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000019668; Expressed in ovary and 12 other tissues.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0031080; C:nuclear pore outer ring; ISS:UniProtKB.
DR GO; GO:0035859; C:Seh1-associated complex; IBA:GO_Central.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR GO; GO:0007080; P:mitotic metaphase plate congression; ISS:UniProtKB.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006999; P:nuclear pore organization; ISS:UniProtKB.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR037597; Nucleoporin_Seh1.
DR InterPro; IPR037363; Sec13/Seh1_fam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR11024; PTHR11024; 1.
DR PANTHER; PTHR11024:SF3; PTHR11024:SF3; 1.
DR Pfam; PF00400; WD40; 2.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW Kinetochore; Lysosome; Membrane; Mitosis; mRNA transport;
KW Nuclear pore complex; Nucleus; Protein transport; Reference proteome;
KW Repeat; Translocation; Transport; WD repeat.
FT CHAIN 1..360
FT /note="Nucleoporin SEH1"
FT /id="PRO_0000373810"
FT REPEAT 10..49
FT /note="WD 1"
FT REPEAT 55..96
FT /note="WD 2"
FT REPEAT 111..152
FT /note="WD 3"
FT REPEAT 160..210
FT /note="WD 4"
FT REPEAT 217..258
FT /note="WD 5"
FT REPEAT 276..315
FT /note="WD 6"
SQ SEQUENCE 360 AA; 39679 MW; 54237948F4932B47 CRC64;
MFVARSIAAD HKDLIHDVSF DFHGRRMATC SSDQSVKVWD KSENGDWHCT ASWKTHSGSV
WRVTWAHPEF GQVLASCSFD RTAAVWEEIV GESNDKLRGQ SHWVKRTTLV DSRTSVTDVK
FAPKHMGLML ATCSADGVVR IYEAPDVMNL SQWSLQHEIS CKLSCSCISW NPSSSRAHSP
MIAVGSDDSS PNIMGKVQIY EYNENTRKYA KAETLMSVSD PVHDIAFAPN LGRSFHILAV
ATKDVRIFTM KPLRKELSSS GGVTKFEIHT VAQFDNHNSQ VWRVSWNITG TVLASSGDDG
TVRLWKANYM DNWKCIGVLK GDGNPVGNSC QGIFGSSVGS AIQSLQNSVN GTSSSGRKHS
