ID   SEHBP_HUMAN             Reviewed;          46 AA.
AC   C0HLU2;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   29-SEP-2021, sequence version 1.
DT   03-AUG-2022, entry version 3.
DE   RecName: Full=Transcriptional regulator SEHBP {ECO:0000305};
DE   AltName: Full=Short ORF-encoded histone-binding protein {ECO:0000303|PubMed:33468658};
DE   AltName: Full=ZNF689 upstream open reading frame protein {ECO:0000305};
GN   Name=ZNF689 {ECO:0000303|PubMed:33468658};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000305}
RP   IDENTIFICATION, FUNCTION, INTERACTION WITH HISTONE H2B; HMGN1 AND HMGN3,
RP   AND SUBCELLULAR LOCATION.
RX   PubMed=33468658; DOI=10.1073/pnas.2021943118;
RA   Koh M., Ahmad I., Ko Y., Zhang Y., Martinez T.F., Diedrich J.K., Chu Q.,
RA   Moresco J.J., Erb M.A., Saghatelian A., Schultz P.G., Bollong M.J.;
RT   "A short ORF-encoded transcriptional regulator.";
RL   Proc. Natl. Acad. Sci. U.S.A. 118:0-0(2021).
CC   -!- FUNCTION: Plays a role in transcription regulation.
CC       {ECO:0000269|PubMed:33468658}.
CC   -!- SUBUNIT: Interacts with histone H2B (PubMed:33468658). Also interacts
CC       with chromatin-binding proteins HMGN1 and HMGN3 (PubMed:33468658).
CC       {ECO:0000269|PubMed:33468658}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33468658}. Cytoplasm
CC       {ECO:0000269|PubMed:33468658}.
CC   -!- MISCELLANEOUS: Encoded in the 5'-untranslated region (5'-UTR) of
CC       ZNF689. {ECO:0000269|PubMed:33468658}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC093249; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   HGNC; HGNC:25173; ZNF689.
DR   neXtProt; NX_C0HLU2; -.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0042393; F:histone binding; IDA:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..46
FT                   /note="Transcriptional regulator SEHBP"
FT                   /id="PRO_0000453426"
SQ   SEQUENCE   46 AA;  5037 MW;  812C9527388F43F3 CRC64;
     MALRSIKSIA GSCLCSRQRR CGSSAAIFPE GIFRCLSPKF GQEFPE