SEL1_SCHPO
ID SEL1_SCHPO Reviewed; 636 AA.
AC O13858; Q9UU73;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Eisosome protein sle1;
DE AltName: Full=SEG1-like eisosome protein 1;
GN Name=sle1; Synonyms=seg1; ORFNames=SPAC1A6.07;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 109-298, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, AND SUBUNIT.
RX PubMed=22869600; DOI=10.1083/jcb.201202097;
RA Moreira K.E., Schuck S., Schrul B., Frohlich F., Moseley J.B.,
RA Walther T.C., Walter P.;
RT "Seg1 controls eisosome assembly and shape.";
RL J. Cell Biol. 198:405-420(2012).
CC -!- FUNCTION: Important for the biogenesis of filamentous eisosomes, large
CC cytoplasmic protein assemblies that localize to specialized domains on
CC the plasma membrane to cluster specific proteins at sites of membrane
CC invaginations. {ECO:0000269|PubMed:22869600}.
CC -!- SUBUNIT: Component of eisosomes, large cytoplasmic protein assemblies
CC that localize to specialized domains termed MCCs on the plasma
CC membrane. {ECO:0000269|PubMed:22869600}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22869600};
CC Peripheral membrane protein {ECO:0000269|PubMed:10759889}; Cytoplasmic
CC side {ECO:0000269|PubMed:22869600}. Cell tip
CC {ECO:0000269|PubMed:22869600}. Note=Localizes to eisosomes.
CC {ECO:0000269|PubMed:22869600}.
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DR EMBL; CU329670; CAB16357.1; -; Genomic_DNA.
DR EMBL; AB027774; BAA87078.1; -; Genomic_DNA.
DR PIR; T38010; T38010.
DR RefSeq; NP_593199.1; NM_001018595.2.
DR AlphaFoldDB; O13858; -.
DR BioGRID; 278944; 15.
DR STRING; 4896.SPAC1A6.07.1; -.
DR iPTMnet; O13858; -.
DR MaxQB; O13858; -.
DR PaxDb; O13858; -.
DR PRIDE; O13858; -.
DR EnsemblFungi; SPAC1A6.07.1; SPAC1A6.07.1:pep; SPAC1A6.07.
DR GeneID; 2542484; -.
DR KEGG; spo:SPAC1A6.07; -.
DR PomBase; SPAC1A6.07; sle1.
DR VEuPathDB; FungiDB:SPAC1A6.07; -.
DR eggNOG; KOG1181; Eukaryota.
DR HOGENOM; CLU_513042_0_0_1; -.
DR InParanoid; O13858; -.
DR OMA; KLFKIRF; -.
DR PRO; PR:O13858; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0051285; C:cell cortex of cell tip; IDA:PomBase.
DR GO; GO:0036286; C:eisosome filament; IDA:PomBase.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007009; P:plasma membrane organization; IC:PomBase.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome.
FT CHAIN 1..636
FT /note="Eisosome protein sle1"
FT /id="PRO_0000304029"
FT REGION 1..297
FT /note="Required for targeting the protein to eisosomes"
FT REGION 111..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..514
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 636 AA; 69794 MW; D704DB95EBD1EDC3 CRC64;
MSHASKNYNA QLTAAAASTA LHGTKKIYNS NENDRAVNSF LGNRTSYGEA VNGSPQYDYM
RSRMSTLGSA NQPMAPPSLR NRSSVYLPTP AGPPQIPVNT GKRYTLTSSS ANYMTKSERQ
MRPPKSYDFP PSQQVRPSTS RSPSYASYNS EEVNFQSYQD PRLLPRTSQM YMPDNNYSPA
VKSPAAQRRS SSYMVPANSR GSPANYNTPY YPTAIPPPIE EYSPSVSLPT SPVAEESYNN
VQRSSTVRNN TTQKSVLKKP SRKMSPAYTS SYRQNSPSSQ VPPVSKKHVI IYENKEGSSS
SESVYEDVFE DFDPSGSNQA SLRSTSTIHY TPSSKRISVI PPNTSNIGSR VVSRSGQNNN
QPAQPGQYNQ QSQPVQSYQS GQSTQHFQPV QPIQPVQSTQ YYQPSSPVQP VQNGVPAPPM
QPVQSTQYYQ PSSPVQPVQN VKPAQPAQPS LEDAAKRRVE EMLRQMDITP TASSTTANNA
YASAEPHPSA FPDDMNSVFS DSSFERERDS GRGRSTNLFS KFKSGRSRSK ASGEAPYSYP
APPVPSVNNA GARLTLRDSG AAPEATYSLR QPSNHAYSEG RSYTFTGGQP PSVPTMPYGS
RFANDSDSMM GSTADFSSKK KGGKFKAFKK FFKMRF
