SEL7_CAEEL
ID SEL7_CAEEL Reviewed; 324 AA.
AC G5EGS7;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Putative transcription factor sel-7 {ECO:0000303|PubMed:19500563};
DE AltName: Full=Suppressor/enhancer of lin-12 protein 7 {ECO:0000312|WormBase:K04G11.2};
GN Name=sel-7 {ECO:0000312|WormBase:K04G11.2};
GN ORFNames=K04G11.2 {ECO:0000312|WormBase:K04G11.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|EMBL:AAQ96213.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, INTERACTION WITH MDT-29,
RP SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE, AND
RP MUTAGENESIS OF 55-ARG--ALA-324 AND 171-GLN--ALA-324.
RX PubMed=15020414; DOI=10.1534/genetics.166.1.151;
RA Chen J., Li X., Greenwald I.;
RT "sel-7, a positive regulator of lin-12 activity, encodes a novel nuclear
RT protein in Caenorhabditis elegans.";
RL Genetics 166:151-160(2004).
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF
RP 171-GLN--ALA-324.
RX PubMed=19500563; DOI=10.1016/j.ydbio.2009.05.574;
RA Xia D., Huang X., Zhang H.;
RT "The temporally regulated transcription factor sel-7 controls developmental
RT timing in C. elegans.";
RL Dev. Biol. 332:246-257(2009).
CC -!- FUNCTION: Putative transcription factor (PubMed:19500563). Positive
CC regulator of the lin-12/Notch signaling pathway (PubMed:15020414).
CC Binds to specific DNA sequences in regulatory elements
CC (PubMed:19500563). Involved in cell fate decisions that require cell-
CC cell interactions, such as the anchor cell (AC) / ventral uterine (VU)
CC precursor cell fate decision (PubMed:15020414). Heterochronic protein
CC which controls the choice of stage specific cell fates, including the
CC larval L3 stage-specific fate of seam cells (PubMed:19500563). Involved
CC in regulating the temporal expression pattern of hunchback-like protein
CC hbl-1, thereby playing a role in the progression between larval stages
CC L2 and L3 (PubMed:19500563). {ECO:0000269|PubMed:15020414,
CC ECO:0000269|PubMed:19500563}.
CC -!- SUBUNIT: Multimer (PubMed:15020414). May interact with mediator complex
CC subunit mdt-29 (PubMed:15020414). {ECO:0000269|PubMed:15020414}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15020414}.
CC -!- TISSUE SPECIFICITY: Widely expressed, including in pharyngeal muscle
CC cells and body wall muscle cells. {ECO:0000269|PubMed:19500563}.
CC -!- DEVELOPMENTAL STAGE: Expressed in seam cells with temporal changes in
CC expression level; undetectable in L1 and L2 larval stages, then
CC expressed at the L3 stage, declining at the late L4 stage and expressed
CC only weakly in young adults (PubMed:19500563). Expressed in the vulval
CC precursor cells (VPCs) (PubMed:15020414). {ECO:0000269|PubMed:15020414,
CC ECO:0000269|PubMed:19500563}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown suppresses the
CC hermaphrodite gonadal development and egg-laying defects in a lin-12
CC mutant background. {ECO:0000269|PubMed:15020414}.
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DR EMBL; AY398504; AAQ96213.1; -; mRNA.
DR EMBL; BX284606; CAB01759.2; -; Genomic_DNA.
DR PIR; T23316; T23316.
DR RefSeq; NP_510392.2; NM_077991.5.
DR STRING; 6239.K04G11.2; -.
DR EnsemblMetazoa; K04G11.2.1; K04G11.2.1; WBGene00004764.
DR GeneID; 181539; -.
DR KEGG; cel:CELE_K04G11.2; -.
DR CTD; 181539; -.
DR WormBase; K04G11.2; CE35893; WBGene00004764; sel-7.
DR eggNOG; ENOG502SIQQ; Eukaryota.
DR HOGENOM; CLU_850682_0_0_1; -.
DR OMA; YFKWDLL; -.
DR OrthoDB; 1032880at2759; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00004764; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0042802; F:identical protein binding; IPI:WormBase.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:WormBase.
DR GO; GO:0046331; P:lateral inhibition; IGI:WormBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:WormBase.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IGI:WormBase.
DR GO; GO:0042659; P:regulation of cell fate specification; IGI:WormBase.
DR GO; GO:0040034; P:regulation of development, heterochronic; IMP:WormBase.
DR GO; GO:0042661; P:regulation of mesodermal cell fate specification; IGI:WormBase.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..324
FT /note="Putative transcription factor sel-7"
FT /id="PRO_0000456143"
FT MUTAGEN 55..324
FT /note="Missing: In ar523; suppresses the hermaphrodite
FT gonadal development defect in a lin-12 mutant background."
FT /evidence="ECO:0000269|PubMed:15020414"
FT MUTAGEN 171..324
FT /note="Missing: In n1253; suppresses the hermaphrodite
FT gonadal development and egg-laying defects in a lin-12
FT mutant background. Defects in larval stage-specific
FT division of seam cells, leading to reiteration of the
FT typical L2 divisions at the L3 stage; phenotype exacerbated
FT in various mutant backgrounds, e.g. in combination with
FT lin-46, or dcr-1 or let-7. Defect in the development and
FT division of distal tip cells (DTCs), located at the tip of
FT each gonad arm. Abnormal timing of expression of hunchback-
FT like protein hbl-1 at the larval L3 stage."
FT /evidence="ECO:0000269|PubMed:15020414,
FT ECO:0000269|PubMed:19500563"
SQ SEQUENCE 324 AA; 36108 MW; FD6EA3908A018E5F CRC64;
MAQPNQPTPQ FQMAQIPLAA FFDNNESKTM LNSMNLRLND MDLKLSLILE LLATRLPDQR
LPSIFTSPPQ TVISEAPPQS FTPSATNSTS DKTSSSLKTE LKTEDSDGDL DMEGEEDTEE
LFDNESQPSQ RNQSPKETEV EDEKVLADGP FPEGAVKRAA EKAARSFQST QPKVFAWQIL
RESVTDDELR NVQISLRTFH GETADHLLGR QLPKIRLVVE ATMKYFKWDL LSTESQLSKA
KLILSHLKNN AKVRNWTLRE GRPNRVAPAT PPVNVDLVWK RYLALLGPAG FTGILPNLPQ
NLCNGGTQSP SIPQIDPSLF KVDA
