SELH_HUMAN
ID SELH_HUMAN Reviewed; 122 AA.
AC Q8IZQ5; Q8N672;
DT 04-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Selenoprotein H {ECO:0000305};
DE Short=SelH;
GN Name=SELENOH {ECO:0000303|PubMed:27645994, ECO:0000312|HGNC:HGNC:18251};
GN Synonyms=C11orf31 {ECO:0000312|HGNC:HGNC:18251}, SELH;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12775843; DOI=10.1126/science.1083516;
RA Kryukov G.V., Castellano S., Novoselov S.V., Lobanov A.V., Zehtab O.,
RA Guigo R., Gladyshev V.N.;
RT "Characterization of mammalian selenoproteomes.";
RL Science 300:1439-1443(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=B-cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-20, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [6]
RP NOMENCLATURE.
RX PubMed=27645994; DOI=10.1074/jbc.m116.756155;
RA Gladyshev V.N., Arner E.S., Berry M.J., Brigelius-Flohe R., Bruford E.A.,
RA Burk R.F., Carlson B.A., Castellano S., Chavatte L., Conrad M.,
RA Copeland P.R., Diamond A.M., Driscoll D.M., Ferreiro A., Flohe L.,
RA Green F.R., Guigo R., Handy D.E., Hatfield D.L., Hesketh J., Hoffmann P.R.,
RA Holmgren A., Hondal R.J., Howard M.T., Huang K., Kim H.Y., Kim I.Y.,
RA Koehrle J., Krol A., Kryukov G.V., Lee B.J., Lee B.C., Lei X.G., Liu Q.,
RA Lescure A., Lobanov A.V., Loscalzo J., Maiorino M., Mariotti M.,
RA Sandeep Prabhu K., Rayman M.P., Rozovsky S., Salinas G., Schmidt E.E.,
RA Schomburg L., Schweizer U., Simonovic M., Sunde R.A., Tsuji P.A.,
RA Tweedie S., Ursini F., Whanger P.D., Zhang Y.;
RT "Selenoprotein gene nomenclature.";
RL J. Biol. Chem. 291:24036-24040(2016).
CC -!- FUNCTION: May be involved in a redox-related process. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SelWTH family. {ECO:0000305}.
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DR EMBL; AF536829; AAN61472.1; -; mRNA.
DR EMBL; BC021122; AAH21122.2; -; mRNA.
DR CCDS; CCDS44602.1; -.
DR RefSeq; NP_001308264.1; NM_001321335.1.
DR RefSeq; NP_734467.1; NM_170746.3.
DR BioGRID; 129373; 27.
DR IntAct; Q8IZQ5; 11.
DR STRING; 9606.ENSP00000373509; -.
DR iPTMnet; Q8IZQ5; -.
DR PhosphoSitePlus; Q8IZQ5; -.
DR SwissPalm; Q8IZQ5; -.
DR BioMuta; SELENOH; -.
DR DMDM; 190352213; -.
DR EPD; Q8IZQ5; -.
DR jPOST; Q8IZQ5; -.
DR MassIVE; Q8IZQ5; -.
DR MaxQB; Q8IZQ5; -.
DR PaxDb; Q8IZQ5; -.
DR PeptideAtlas; Q8IZQ5; -.
DR PRIDE; Q8IZQ5; -.
DR ProteomicsDB; 71406; -.
DR Antibodypedia; 62795; 12 antibodies from 6 providers.
DR DNASU; 280636; -.
DR Ensembl; ENST00000388857.8; ENSP00000373509.4; ENSG00000211450.11.
DR Ensembl; ENST00000534355.6; ENSP00000434511.1; ENSG00000211450.11.
DR GeneID; 280636; -.
DR KEGG; hsa:280636; -.
DR MANE-Select; ENST00000534355.6; ENSP00000434511.1; NM_170746.4; NP_734467.1.
DR UCSC; uc021qjj.2; human.
DR CTD; 280636; -.
DR DisGeNET; 280636; -.
DR GeneCards; SELENOH; -.
DR HGNC; HGNC:18251; SELENOH.
DR HPA; ENSG00000211450; Low tissue specificity.
DR MIM; 607914; gene.
DR neXtProt; NX_Q8IZQ5; -.
DR OpenTargets; ENSG00000211450; -.
DR PharmGKB; PA25495; -.
DR VEuPathDB; HostDB:ENSG00000211450; -.
DR eggNOG; ENOG502S3QJ; Eukaryota.
DR GeneTree; ENSGT00940000163915; -.
DR HOGENOM; CLU_164858_0_0_1; -.
DR InParanoid; Q8IZQ5; -.
DR OMA; WHNAEEV; -.
DR OrthoDB; 1563553at2759; -.
DR PhylomeDB; Q8IZQ5; -.
DR TreeFam; TF343373; -.
DR PathwayCommons; Q8IZQ5; -.
DR SignaLink; Q8IZQ5; -.
DR BioGRID-ORCS; 280636; 19 hits in 1068 CRISPR screens.
DR ChiTaRS; SELENOH; human.
DR GenomeRNAi; 280636; -.
DR Pharos; Q8IZQ5; Tbio.
DR PRO; PR:Q8IZQ5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8IZQ5; protein.
DR Bgee; ENSG00000211450; Expressed in right adrenal gland cortex and 156 other tissues.
DR ExpressionAtlas; Q8IZQ5; baseline and differential.
DR Genevisible; Q8IZQ5; HS.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR InterPro; IPR011893; Selenoprotein_Rdx-typ.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF10262; Rdx; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR TIGRFAMs; TIGR02174; CXXU_selWTH; 1.
PE 1: Evidence at protein level;
KW Acetylation; Redox-active center; Reference proteome; Selenocysteine.
FT CHAIN 1..122
FT /note="Selenoprotein H"
FT /id="PRO_0000097667"
FT NON_STD 44
FT /note="Selenocysteine"
FT MOD_RES 20
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:19608861"
FT CROSSLNK 41..44
FT /note="Cysteinyl-selenocysteine (Cys-Sec); redox-active"
FT /evidence="ECO:0000250"
SQ SEQUENCE 122 AA; 13453 MW; B7EF30180573D4D5 CRC64;
MAPRGRKRKA EAAVVAVAEK REKLANGGEG MEEATVVIEH CTSURVYGRN AAALSQALRL
EAPELPVKVN PTKPRRGSFE VTLLRPDGSS AELWTGIKKG PPRKLKFPEP QEVVEELKKY
LS