SELH_MOUSE
ID SELH_MOUSE Reviewed; 116 AA.
AC Q3UQA7; Q7TNQ0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Selenoprotein H {ECO:0000250|UniProtKB:Q8IZQ5};
DE Short=SelH;
GN Name=Selenoh {ECO:0000312|MGI:MGI:1919907};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Mammary gland, Placenta, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in a redox-related process. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SelWTH family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK012609; BAE43233.1; -; mRNA.
DR EMBL; AK142622; BAE25135.1; -; mRNA.
DR EMBL; AK167638; BAE39689.1; -; mRNA.
DR EMBL; AK171972; BAE42753.1; -; mRNA.
DR EMBL; BC056177; AAH56177.2; -; mRNA.
DR CCDS; CCDS16187.1; -.
DR RefSeq; NP_001028338.1; NM_001033166.3.
DR RefSeq; NP_001032356.1; NM_001037279.2.
DR BioGRID; 215495; 2.
DR STRING; 10090.ENSMUSP00000112635; -.
DR iPTMnet; Q3UQA7; -.
DR PhosphoSitePlus; Q3UQA7; -.
DR EPD; Q3UQA7; -.
DR jPOST; Q3UQA7; -.
DR MaxQB; Q3UQA7; -.
DR PaxDb; Q3UQA7; -.
DR PeptideAtlas; Q3UQA7; -.
DR PRIDE; Q3UQA7; -.
DR ProteomicsDB; 255378; -.
DR Antibodypedia; 62795; 12 antibodies from 6 providers.
DR Ensembl; ENSMUST00000102646; ENSMUSP00000099706; ENSMUSG00000076437.
DR Ensembl; ENSMUST00000102647; ENSMUSP00000099707; ENSMUSG00000076437.
DR Ensembl; ENSMUST00000117299; ENSMUSP00000112635; ENSMUSG00000076437.
DR GeneID; 72657; -.
DR KEGG; mmu:72657; -.
DR UCSC; uc008kiv.1; mouse.
DR CTD; 280636; -.
DR MGI; MGI:1919907; Selenoh.
DR VEuPathDB; HostDB:ENSMUSG00000076437; -.
DR eggNOG; ENOG502S3QJ; Eukaryota.
DR GeneTree; ENSGT00940000163915; -.
DR HOGENOM; CLU_164858_0_0_1; -.
DR InParanoid; Q3UQA7; -.
DR OMA; WHNAEEV; -.
DR OrthoDB; 1563553at2759; -.
DR PhylomeDB; Q3UQA7; -.
DR TreeFam; TF343373; -.
DR BioGRID-ORCS; 72657; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q3UQA7; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q3UQA7; protein.
DR Bgee; ENSMUSG00000076437; Expressed in 1st arch maxillary component and 251 other tissues.
DR ExpressionAtlas; Q3UQA7; baseline and differential.
DR Genevisible; Q3UQA7; MM.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR InterPro; IPR011893; Selenoprotein_Rdx-typ.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF10262; Rdx; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR TIGRFAMs; TIGR02174; CXXU_selWTH; 1.
PE 1: Evidence at protein level;
KW Acetylation; Redox-active center; Reference proteome; Selenocysteine.
FT CHAIN 1..116
FT /note="Selenoprotein H"
FT /id="PRO_0000318631"
FT NON_STD 38
FT /note="Selenocysteine"
FT MOD_RES 20
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZQ5"
FT CROSSLNK 35..38
FT /note="Cysteinyl-selenocysteine (Cys-Sec); redox-active"
FT /evidence="ECO:0000250"
SQ SEQUENCE 116 AA; 12974 MW; 3E3985825D6995A4 CRC64;
MAPHGRKRKA GAAPMETVDK REKLAEGATV VIEHCTSURV YGRHAAALSQ ALQLEAPELP
VQVNPSKPRR GSFEVTLLRS DNSRVELWTG IKKGPPRKLK FPEPQEVVEE LKKYLS
