ID   SELK_DANRE              Reviewed;          94 AA.
AC   Q66I79;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 3.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Selenoprotein K {ECO:0000250|UniProtKB:Q9Y6D0};
DE            Short=SelK;
GN   Name=selenok; Synonyms=selk;
GN   ORFNames=zgc:103591 {ECO:0000312|EMBL:AAH81491.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for Ca(2+) flux in immune cells and plays a role in
CC       T-cell proliferation and in T-cell and neutrophil migration (By
CC       similarity). Involved in endoplasmic reticulum-associated degradation
CC       (ERAD) of soluble glycosylated proteins (By similarity). Required for
CC       cell surface expression of CD36 and involved in macrophage uptake of
CC       low-density lipoprotein and in foam cell formation (By similarity).
CC       Required for palmitoylation (By similarity).
CC       {ECO:0000250|UniProtKB:Q9JLJ1, ECO:0000250|UniProtKB:Q9Y6D0}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9Y6D0}; Single-pass membrane protein
CC       {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9Y6D0}; Single-
CC       pass membrane protein {ECO:0000255}. Note=Probably mainly localized in
CC       the ER. {ECO:0000250|UniProtKB:Q9Y6D0}.
CC   -!- SIMILARITY: Belongs to the selenoprotein K family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH81491.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC081491; AAH81491.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001004681.2; NM_001004681.3.
DR   STRING; 7955.ENSDARP00000066451; -.
DR   PaxDb; Q66I79; -.
DR   GeneID; 791738; -.
DR   KEGG; dre:791738; -.
DR   CTD; 58515; -.
DR   ZFIN; ZDB-GENE-040912-131; selenok.
DR   eggNOG; ENOG502S3PW; Eukaryota.
DR   InParanoid; Q66I79; -.
DR   OrthoDB; 1566291at2759; -.
DR   PhylomeDB; Q66I79; -.
DR   PRO; PR:Q66I79; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006816; P:calcium ion transport; IBA:GO_Central.
DR   GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
DR   GO; GO:0018345; P:protein palmitoylation; ISS:UniProtKB.
DR   InterPro; IPR024491; Se_SelK/SelG.
DR   PANTHER; PTHR16875; PTHR16875; 1.
DR   Pfam; PF10961; SelK_SelG; 1.
PE   3: Inferred from homology;
KW   Calcium; Calcium transport; Cell membrane; Endoplasmic reticulum;
KW   Ion transport; Membrane; Reference proteome; Selenocysteine; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..94
FT                   /note="Selenoprotein K"
FT                   /id="PRO_0000290205"
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          45..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..59
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_STD         92
FT                   /note="Selenocysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   94 AA;  10153 MW;  E81FFC261949EF78 CRC64;
     MVYVSNGQVL DSRSRSPWSL SFLTDFFWGA VEFIGLFFQT LVQPDLSKDG NNSASSRFSD
     GRGPPGFPGR RRMGRINHGA GPTPPPMGGG GUGR