SELK_RAT
ID SELK_RAT Reviewed; 94 AA.
AC P59798; Q5I0Q3;
DT 04-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Selenoprotein K {ECO:0000250|UniProtKB:Q9Y6D0};
DE Short=SelK {ECO:0000250|UniProtKB:Q9Y6D0};
GN Name=Selenok {ECO:0000312|RGD:1303129};
GN Synonyms=Selk {ECO:0000312|RGD:1303129};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain stem;
RA Zhou L., Guo J., Ma Y.;
RT "Rattus norvegicus heat shock protein.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Required for Ca(2+) flux in immune cells and plays a role in
CC T-cell proliferation and in T-cell and neutrophil migration (By
CC similarity). Involved in endoplasmic reticulum-associated degradation
CC (ERAD) of soluble glycosylated proteins (By similarity). Required for
CC palmitoylation and cell surface expression of CD36 and involved in
CC macrophage uptake of low-density lipoprotein and in foam cell formation
CC (By similarity). Together with ZDHHC6, required for palmitoylation of
CC ITPR1 in immune cells, leading to regulate ITPR1 stability and
CC function. Plays a role in protection of cells from ER stress-induced
CC apoptosis. Protects cells from oxidative stress when overexpressed in
CC cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:Q9JLJ1,
CC ECO:0000250|UniProtKB:Q9Y6D0}.
CC -!- SUBUNIT: Interacts with DERL1, DERL2, DERL3 and SELENOS. The SELENOK-
CC SELENOS complex interacts with VCP. Interacts with ZDHHC6.
CC {ECO:0000250|UniProtKB:Q9Y6D0}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q9Y6D0}; Single-pass membrane protein
CC {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9Y6D0}; Single-
CC pass membrane protein {ECO:0000255}. Note=Probably mainly localized in
CC the ER. {ECO:0000250|UniProtKB:Q9Y6D0}.
CC -!- PTM: Cleaved by CAPN2/m-calpain in resting macrophages but not in
CC activated macrophages. Macrophage activation up-regulates expression of
CC the calpain inhibitor CAST/calpastatin, resulting in inhibition of
CC CAPN2 activity (By similarity). {ECO:0000250|UniProtKB:Q9JLJ1}.
CC -!- PTM: Truncated SELENOK proteins produced by failed UGA/Sec decoding are
CC ubiquitinated by the CRL2(KLHDC2) complex, which recognizes the
CC diglycine (Gly-Gly) at the C-terminus of truncated SELENOK proteins.
CC {ECO:0000250|UniProtKB:Q9Y6D0}.
CC -!- SIMILARITY: Belongs to the selenoprotein K family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP73816.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY319924; AAP73816.1; ALT_SEQ; mRNA.
DR EMBL; BC088086; AAH88086.2; -; mRNA.
DR RefSeq; NP_997472.2; NM_207589.4.
DR STRING; 10116.ENSRNOP00000020284; -.
DR jPOST; P59798; -.
DR PaxDb; P59798; -.
DR Ensembl; ENSRNOT00000020284; ENSRNOP00000020284; ENSRNOG00000014624.
DR GeneID; 290549; -.
DR KEGG; rno:290549; -.
DR UCSC; RGD:1303129; rat.
DR CTD; 58515; -.
DR RGD; 1303129; Selenok.
DR eggNOG; ENOG502S3PW; Eukaryota.
DR GeneTree; ENSGT00390000016119; -.
DR InParanoid; P59798; -.
DR OrthoDB; 1566291at2759; -.
DR PhylomeDB; P59798; -.
DR TreeFam; TF328380; -.
DR PRO; PR:P59798; -.
DR Proteomes; UP000002494; Chromosome 16.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0006816; P:calcium ion transport; ISO:RGD.
DR GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
DR GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; ISO:RGD.
DR GO; GO:0010742; P:macrophage derived foam cell differentiation; ISO:RGD.
DR GO; GO:0030335; P:positive regulation of cell migration; ISO:RGD.
DR GO; GO:0032722; P:positive regulation of chemokine production; ISO:RGD.
DR GO; GO:0002230; P:positive regulation of defense response to virus by host; ISO:RGD.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; ISO:RGD.
DR GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; ISO:RGD.
DR GO; GO:2000406; P:positive regulation of T cell migration; ISO:RGD.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; ISO:RGD.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISO:RGD.
DR GO; GO:0018345; P:protein palmitoylation; ISS:UniProtKB.
DR GO; GO:0050848; P:regulation of calcium-mediated signaling; ISO:RGD.
DR GO; GO:0051223; P:regulation of protein transport; ISO:RGD.
DR GO; GO:0045728; P:respiratory burst after phagocytosis; ISO:RGD.
DR GO; GO:0006979; P:response to oxidative stress; ISO:RGD.
DR InterPro; IPR024491; Se_SelK/SelG.
DR PANTHER; PTHR16875; PTHR16875; 1.
DR Pfam; PF10961; SelK_SelG; 1.
PE 3: Inferred from homology;
KW Calcium; Calcium transport; Cell membrane; Endoplasmic reticulum;
KW Ion transport; Membrane; Reference proteome; Selenocysteine; Transmembrane;
KW Transmembrane helix; Transport; Ubl conjugation.
FT CHAIN 1..94
FT /note="Selenoprotein K"
FT /id="PRO_0000097671"
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 49..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 81..82
FT /note="Cleavage; by CAPN2"
FT /evidence="ECO:0000250"
FT NON_STD 92
FT /note="Selenocysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 94 AA; 10626 MW; D10B0C633FEB5607 CRC64;
MVYISNGQVL DSRNQSPWRL SFITDFFWGI AEFVVFFFKT LLQQDVKKRR GYGGSSDSRY
DDGRGPPGNP PRRMGRISHL RGPSPPPMAG GUGR
