ID   SELK_XENLA              Reviewed;          95 AA.
AC   Q641S4;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 3.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Selenoprotein K {ECO:0000250|UniProtKB:Q9Y6D0};
DE            Short=SelK;
GN   Name=selenok; Synonyms=selk;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for Ca(2+) flux in immune cells and plays a role in
CC       T-cell proliferation and in T-cell and neutrophil migration (By
CC       similarity). Involved in endoplasmic reticulum-associated degradation
CC       (ERAD) of soluble glycosylated proteins (By similarity). Required for
CC       cell surface expression of CD36 and involved in macrophage uptake of
CC       low-density lipoprotein and in foam cell formation (By similarity).
CC       Required for palmitoylation (By similarity).
CC       {ECO:0000250|UniProtKB:Q9JLJ1, ECO:0000250|UniProtKB:Q9Y6D0}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9Y6D0}; Single-pass membrane protein
CC       {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9Y6D0}; Single-
CC       pass membrane protein {ECO:0000255}. Note=Probably mainly localized in
CC       the ER. {ECO:0000250|UniProtKB:Q9Y6D0}.
CC   -!- SIMILARITY: Belongs to the selenoprotein K family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH82203.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC082203; AAH82203.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001087951.2; NM_001094482.2.
DR   DNASU; 494630; -.
DR   GeneID; 494630; -.
DR   KEGG; xla:494630; -.
DR   CTD; 494630; -.
DR   Xenbase; XB-GENE-5939253; selenok.S.
DR   OrthoDB; 1566291at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 494630; Expressed in testis and 19 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0018345; P:protein palmitoylation; ISS:UniProtKB.
DR   InterPro; IPR024491; Se_SelK/SelG.
DR   PANTHER; PTHR16875; PTHR16875; 1.
DR   Pfam; PF10961; SelK_SelG; 1.
PE   3: Inferred from homology;
KW   Calcium; Calcium transport; Cell membrane; Endoplasmic reticulum;
KW   Ion transport; Membrane; Reference proteome; Selenocysteine; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..95
FT                   /note="Selenoprotein K"
FT                   /id="PRO_0000290206"
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          47..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..61
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_STD         93
FT                   /note="Selenocysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   95 AA;  10418 MW;  08DB94CE9754B786 CRC64;
     MVYISNGQVL DGQSRSPWRL SFLTDMFWGI TDFVVMFFQS IIHPNVTRRG CQNSSSSTRY
     DDGRGPPGHP RRMGRINHGS GPSAPPMAGG GGUGR