ID   SELK_XENTR              Reviewed;          95 AA.
AC   Q01H83;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Selenoprotein K {ECO:0000250|UniProtKB:Q9Y6D0};
DE            Short=SelK;
GN   Name=selenok; Synonyms=selk;
GN   ORFNames=TGas073e13.1 {ECO:0000312|EMBL:CAL50708.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for Ca(2+) flux in immune cells and plays a role in
CC       T-cell proliferation and in T-cell and neutrophil migration (By
CC       similarity). Involved in endoplasmic reticulum-associated degradation
CC       (ERAD) of soluble glycosylated proteins (By similarity). Required for
CC       cell surface expression of CD36 and involved in macrophage uptake of
CC       low-density lipoprotein and in foam cell formation (By similarity).
CC       Required for palmitoylation (By similarity).
CC       {ECO:0000250|UniProtKB:Q9JLJ1, ECO:0000250|UniProtKB:Q9Y6D0}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9Y6D0}; Single-pass membrane protein
CC       {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9Y6D0}; Single-
CC       pass membrane protein {ECO:0000255}. Note=Probably mainly localized in
CC       the ER. {ECO:0000250|UniProtKB:Q9Y6D0}.
CC   -!- SIMILARITY: Belongs to the selenoprotein K family. {ECO:0000305}.
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DR   EMBL; CR942388; CAL50708.1; -; mRNA.
DR   RefSeq; NP_001072180.1; NM_001078712.1.
DR   STRING; 8364.ENSXETP00000054287; -.
DR   PaxDb; Q01H83; -.
DR   GeneID; 779591; -.
DR   KEGG; xtr:779591; -.
DR   CTD; 58515; -.
DR   Xenbase; XB-GENE-5939196; selenok.
DR   eggNOG; ENOG502S3PW; Eukaryota.
DR   HOGENOM; CLU_182590_0_1_1; -.
DR   InParanoid; Q01H83; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006816; P:calcium ion transport; IBA:GO_Central.
DR   GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IBA:GO_Central.
DR   GO; GO:0018345; P:protein palmitoylation; ISS:UniProtKB.
DR   InterPro; IPR024491; Se_SelK/SelG.
DR   PANTHER; PTHR16875; PTHR16875; 1.
DR   Pfam; PF10961; SelK_SelG; 1.
PE   3: Inferred from homology;
KW   Calcium; Calcium transport; Cell membrane; Endoplasmic reticulum;
KW   Ion transport; Membrane; Reference proteome; Selenocysteine; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..95
FT                   /note="Selenoprotein K"
FT                   /id="PRO_0000290207"
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          48..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..78
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_STD         93
FT                   /note="Selenocysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   95 AA;  10646 MW;  C9E767C7E09047A7 CRC64;
     MVYIANGQVL DGQSRSPWRL SFLTDMFWGI TDFIVMFFQS IIHPNVTRRG CQNSSSRTRF
     DDGRGPPGNP RRRMGRIDHN SGPNAPPMSG GGUGR