ID   SELM_ERISI              Reviewed;         129 AA.
AC   G4WAW9;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   11-DEC-2019, entry version 17.
DE   RecName: Full=Selenoprotein M {ECO:0000303|PubMed:21557973};
DE   Flags: Precursor;
GN   Name=Selenom {ECO:0000250|UniProtKB:Q8WWX9};
GN   Synonyms=SelM {ECO:0000312|EMBL:ADU25500.1};
OS   Eriocheir sinensis (Chinese mitten crab).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC   Eubrachyura; Grapsoidea; Varunidae; Eriocheir.
OX   NCBI_TaxID=95602;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ADU25500.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RC   TISSUE=Hepatopancreas {ECO:0000269|PubMed:21557973};
RX   PubMed=21557973; DOI=10.1016/j.peptides.2011.04.022;
RA   Lu W., Li W.W., Jin X.K., He L., Jiang H., Wang Q.;
RT   "Reproductive function of Selenoprotein M in Chinese mitten crabs
RT   (Eriocheir sinesis).";
RL   Peptides 34:168-176(2012).
CC   -!- FUNCTION: May function as a thiol-disulfide oxidoreductase that
CC       participates in disulfide bond formation. Involved in the regulation of
CC       reproduction during the period of rapid gonadal development.
CC       {ECO:0000269|PubMed:21557973}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: High expression levels observed in hepatopancreas,
CC       testis, ovaries and intestine. Also expressed in heart, stomach, gills,
CC       cranial ganglia, muscle and hematocytes. {ECO:0000269|PubMed:21557973}.
CC   -!- DEVELOPMENTAL STAGE: During reproduction, expression in ovary and
CC       testis increases rapidly and significantly at stage III-1 (August-
CC       September), with peak expression being reached in September. The
CC       highest expression level in the hepatopancreas is detected at stage IV.
CC       In hemolymph, the expression is high during stage III-1, and then
CC       decreases significantly from stage III-2 onwards.
CC       {ECO:0000269|PubMed:21557973}.
CC   -!- SIMILARITY: Belongs to the selenoprotein M/F family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HQ259302; ADU25500.1; -; mRNA.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.30.50; -; 1.
DR   InterPro; IPR038219; Sep15/SelM_sf.
DR   InterPro; IPR039992; Sep15_SelM.
DR   InterPro; IPR014912; Sep15_SelM_dom.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR13077; PTHR13077; 1.
DR   Pfam; PF08806; Sep15_SelM; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Selenium; Selenocysteine; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..129
FT                   /note="Selenoprotein M"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000416969"
FT   MOTIF           126..129
FT                   /note="Prevents secretion from ER"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        35
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        38
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   NON_STD         38
FT                   /note="Selenocysteine"
FT                   /evidence="ECO:0000269|PubMed:21557973"
SQ   SEQUENCE   129 AA;  14699 MW;  DE50432147E01DF5 CRC64;
     MARGLAVFFL LAGACLALAE DVVDKGVAKA RVESCSGUQL NRYPGAKQFI QEDLPLFHNT
     KFQHIGGAAP ELLLLNKQDQ ELERFDLKKL SREEINELMI KKGFYKKSSK DEQVPEEYQE
     GPYMEKEEL