SELM_HUMAN
ID SELM_HUMAN Reviewed; 145 AA.
AC Q8WWX9; A8MPZ2;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 3.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Selenoprotein M {ECO:0000303|PubMed:27645994};
DE Short=SelM {ECO:0000303|PubMed:27645994};
DE Flags: Precursor;
GN Name=SELENOM {ECO:0000303|PubMed:27645994, ECO:0000312|HGNC:HGNC:30397};
GN Synonyms=SELM {ECO:0000303|PubMed:11839807, ECO:0000303|PubMed:27645994};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=11839807; DOI=10.1128/mcb.22.5.1402-1411.2002;
RA Korotkov K.V., Novoselov S.V., Hatfield D.L., Gladyshev V.N.;
RT "Mammalian selenoprotein in which selenocysteine (Sec) incorporation is
RT supported by a new form of Sec insertion sequence element.";
RL Mol. Cell. Biol. 22:1402-1411(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NOMENCLATURE.
RX PubMed=27645994; DOI=10.1074/jbc.m116.756155;
RA Gladyshev V.N., Arner E.S., Berry M.J., Brigelius-Flohe R., Bruford E.A.,
RA Burk R.F., Carlson B.A., Castellano S., Chavatte L., Conrad M.,
RA Copeland P.R., Diamond A.M., Driscoll D.M., Ferreiro A., Flohe L.,
RA Green F.R., Guigo R., Handy D.E., Hatfield D.L., Hesketh J., Hoffmann P.R.,
RA Holmgren A., Hondal R.J., Howard M.T., Huang K., Kim H.Y., Kim I.Y.,
RA Koehrle J., Krol A., Kryukov G.V., Lee B.J., Lee B.C., Lei X.G., Liu Q.,
RA Lescure A., Lobanov A.V., Loscalzo J., Maiorino M., Mariotti M.,
RA Sandeep Prabhu K., Rayman M.P., Rozovsky S., Salinas G., Schmidt E.E.,
RA Schomburg L., Schweizer U., Simonovic M., Sunde R.A., Tsuji P.A.,
RA Tweedie S., Ursini F., Whanger P.D., Zhang Y.;
RT "Selenoprotein gene nomenclature.";
RL J. Biol. Chem. 291:24036-24040(2016).
CC -!- FUNCTION: May function as a thiol-disulfide oxidoreductase that
CC participates in disulfide bond formation. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8WWX9; P61604: HSPE1; NbExp=3; IntAct=EBI-10277687, EBI-711483;
CC Q8WWX9; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-10277687, EBI-11749135;
CC Q8WWX9; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-10277687, EBI-11953334;
CC Q8WWX9; Q99750: MDFI; NbExp=3; IntAct=EBI-10277687, EBI-724076;
CC Q8WWX9; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-10277687, EBI-742948;
CC Q8WWX9; Q7RTP0: NIPA1; NbExp=3; IntAct=EBI-10277687, EBI-17702144;
CC Q8WWX9; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10277687, EBI-945833;
CC Q8WWX9; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-10277687, EBI-7545592;
CC Q8WWX9; Q9BY50: SEC11C; NbExp=3; IntAct=EBI-10277687, EBI-2855401;
CC Q8WWX9; Q96EQ0: SGTB; NbExp=5; IntAct=EBI-10277687, EBI-744081;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000269|PubMed:11839807}. Endoplasmic reticulum
CC {ECO:0000305|PubMed:11839807}. Golgi apparatus
CC {ECO:0000305|PubMed:11839807}. Note=Localized to perinuclear structures
CC corresponding to Golgi and endoplasmic reticulum.
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11839807}.
CC -!- SIMILARITY: Belongs to the selenoprotein M/F family. {ECO:0000305}.
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DR EMBL; AY043487; AAK95397.1; -; mRNA.
DR EMBL; AC005005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC013421; AAH13421.1; -; mRNA.
DR EMBL; BC030236; AAH30236.1; -; mRNA.
DR EMBL; BC068004; AAH68004.1; -; mRNA.
DR CCDS; CCDS43003.1; -.
DR RefSeq; NP_536355.1; NM_080430.3.
DR BioGRID; 126635; 19.
DR IntAct; Q8WWX9; 12.
DR STRING; 9606.ENSP00000384564; -.
DR MetOSite; Q8WWX9; -.
DR PhosphoSitePlus; Q8WWX9; -.
DR BioMuta; SELENOM; -.
DR DMDM; 189034058; -.
DR EPD; Q8WWX9; -.
DR jPOST; Q8WWX9; -.
DR MassIVE; Q8WWX9; -.
DR MaxQB; Q8WWX9; -.
DR PaxDb; Q8WWX9; -.
DR PeptideAtlas; Q8WWX9; -.
DR PRIDE; Q8WWX9; -.
DR ProteomicsDB; 74954; -.
DR Antibodypedia; 5738; 132 antibodies from 19 providers.
DR DNASU; 140606; -.
DR Ensembl; ENST00000400299.6; ENSP00000383155.2; ENSG00000198832.11.
DR Ensembl; ENST00000402395.5; ENSP00000384564.1; ENSG00000198832.11.
DR GeneID; 140606; -.
DR KEGG; hsa:140606; -.
DR MANE-Select; ENST00000400299.6; ENSP00000383155.2; NM_080430.4; NP_536355.1.
DR CTD; 140606; -.
DR DisGeNET; 140606; -.
DR GeneCards; SELENOM; -.
DR HGNC; HGNC:30397; SELENOM.
DR HPA; ENSG00000198832; Low tissue specificity.
DR MIM; 610918; gene.
DR neXtProt; NX_Q8WWX9; -.
DR OpenTargets; ENSG00000198832; -.
DR VEuPathDB; HostDB:ENSG00000198832; -.
DR eggNOG; ENOG502S29K; Eukaryota.
DR GeneTree; ENSGT00940000154284; -.
DR InParanoid; Q8WWX9; -.
DR OMA; TFRPDWN; -.
DR OrthoDB; 1621104at2759; -.
DR PhylomeDB; Q8WWX9; -.
DR PathwayCommons; Q8WWX9; -.
DR SignaLink; Q8WWX9; -.
DR BioGRID-ORCS; 140606; 8 hits in 1035 CRISPR screens.
DR ChiTaRS; SELENOM; human.
DR GenomeRNAi; 140606; -.
DR Pharos; Q8WWX9; Tdark.
DR PRO; PR:Q8WWX9; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q8WWX9; protein.
DR Bgee; ENSG00000198832; Expressed in mucosa of stomach and 169 other tissues.
DR ExpressionAtlas; Q8WWX9; baseline and differential.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0060612; P:adipose tissue development; IEA:Ensembl.
DR GO; GO:0035934; P:corticosterone secretion; IEA:Ensembl.
DR GO; GO:0042445; P:hormone metabolic process; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0010269; P:response to selenium ion; IEA:Ensembl.
DR Gene3D; 3.40.30.50; -; 1.
DR InterPro; IPR038219; Sep15/SelM_sf.
DR InterPro; IPR039992; Sep15_SelM.
DR InterPro; IPR014912; Sep15_SelM_dom.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR13077; PTHR13077; 1.
DR Pfam; PF08806; Sep15_SelM; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Endoplasmic reticulum; Golgi apparatus; Reference proteome;
KW Selenocysteine; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..145
FT /note="Selenoprotein M"
FT /id="PRO_0000022298"
FT ACT_SITE 45
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT ACT_SITE 48
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT NON_STD 48
FT /note="Selenocysteine"
FT CROSSLNK 45..48
FT /note="Cysteinyl-selenocysteine (Cys-Sec)"
FT /evidence="ECO:0000255"
SQ SEQUENCE 145 AA; 16232 MW; 556A41B02EF694BE CRC64;
MSLLLPPLAL LLLLAALVAP ATAATAYRPD WNRLSGLTRA RVETCGGUQL NRLKEVKAFV
TQDIPFYHNL VMKHLPGADP ELVLLGRRYE ELERIPLSEM TREEINALVQ ELGFYRKAAP
DAQVPPEYVW APAKPPEETS DHADL
