ID   SELM_XENLA              Reviewed;         136 AA.
AC   Q6GP98;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Selenoprotein M {ECO:0000250|UniProtKB:Q8WWX9};
DE            Short=SelM;
DE   Flags: Precursor;
GN   Name=selenom; Synonyms=selm;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a thiol-disulfide oxidoreductase that
CC       participates in disulfide bond formation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the selenoprotein M/F family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH73243.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC073243; AAH73243.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001085717.2; NM_001092248.2.
DR   DNASU; 444144; -.
DR   GeneID; 444144; -.
DR   KEGG; xla:444144; -.
DR   CTD; 444144; -.
DR   Xenbase; XB-GENE-6255960; selenom.L.
DR   OrthoDB; 1621104at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 444144; Expressed in pancreas and 18 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.30.50; -; 1.
DR   InterPro; IPR038219; Sep15/SelM_sf.
DR   InterPro; IPR039992; Sep15_SelM.
DR   InterPro; IPR014912; Sep15_SelM_dom.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR13077; PTHR13077; 1.
DR   Pfam; PF08806; Sep15_SelM; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Reference proteome; Selenocysteine; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..136
FT                   /note="Selenoprotein M"
FT                   /id="PRO_0000318608"
FT   REGION          108..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           133..136
FT                   /note="Prevents secretion from ER"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        38
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        41
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   NON_STD         41
FT                   /note="Selenocysteine"
FT                   /evidence="ECO:0000250"
FT   CROSSLNK        38..41
FT                   /note="Cysteinyl-selenocysteine (Cys-Sec)"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   136 AA;  15619 MW;  047ECD8AB97DA01B CRC64;
     MWLPLPLLLG LLQLQPILSY QIDWNKLERI NRGKVESCGG UQLNRLKEVK GFVTEDLPLY
     HNLEMKHIPG ADPELVLITS RYEELERIPL SDMKRDEINQ LLKDLGFYRK SSPDAPVPAE
     FKMAPARASG DTKEDL