ID   SELN_XENTR              Reviewed;         562 AA.
AC   Q01H84; Q6P3Q2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Selenoprotein N {ECO:0000250|UniProtKB:Q9NZV5};
DE            Short=SelN {ECO:0000250|UniProtKB:Q9NZV5};
GN   Name=selenon; Synonyms=sepn1;
GN   ORFNames=TEgg073a06.1 {ECO:0000312|EMBL:CAL50709.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in cell protection against oxidative
CC       stress and in the regulation of redox-related calcium homeostasis.
CC       Regulates the calcium level of the ER by protecting the calcium pump
CC       ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Acts
CC       as a modulator of ryanodine receptor (RyR) activity. Plays an important
CC       role in muscle development and differentiation during early
CC       development. {ECO:0000250|UniProtKB:Q3Y4E2,
CC       ECO:0000250|UniProtKB:Q9NZV5}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9NZV5}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH63905.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAH63905.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CR855533; CAL50709.1; -; mRNA.
DR   EMBL; BC063905; AAH63905.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001070901.1; NM_001077433.2.
DR   STRING; 8364.ENSXETP00000023401; -.
DR   PaxDb; Q01H84; -.
DR   Ensembl; ENSXETT00000023401; ENSXETP00000023401; ENSXETG00000010686.
DR   GeneID; 394859; -.
DR   KEGG; xtr:394859; -.
DR   CTD; 57190; -.
DR   Xenbase; XB-GENE-6456840; selenon.
DR   eggNOG; ENOG502QREI; Eukaryota.
DR   InParanoid; Q01H84; -.
DR   OrthoDB; 817333at2759; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000010686; Expressed in neurula embryo and 13 other tissues.
DR   ExpressionAtlas; Q01H84; baseline.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0055074; P:calcium ion homeostasis; IBA:GO_Central.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IBA:GO_Central.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Oxidoreductase;
KW   Reference proteome; Selenocysteine; Transmembrane; Transmembrane helix.
FT   CHAIN           1..562
FT                   /note="Selenoprotein N"
FT                   /id="PRO_0000318632"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_STD         436
FT                   /note="Selenocysteine"
FT   CARBOHYD        163
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        310
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        457
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        503
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        44
FT                   /note="L -> S (in Ref. 2; AAH63905)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        104
FT                   /note="S -> A (in Ref. 2; AAH63905)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        113
FT                   /note="T -> A (in Ref. 2; AAH63905)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   562 AA;  64071 MW;  A0B6FA0C533C00DC CRC64;
     MSADLRKRKK DTTADNDAPQ EAQAEEENKK EKPSSCRYRF LWKLLLGLLL IALLFGIKIH
     RDNELVRQQE AALRTLGAEG LFLFSSLDTD NDMHISPEEF KPISEKLTGI STTSDYEEEE
     LLDPNGETLS VASRFQPLLM ETMTKSKDGF LGITHSALSG LRNWTTPVVP NNVFYAGQFK
     AFLPPKNKLE VGNPWWIIPS ELSIFTGYLP NNRIYPPPPK GKEVIIHKLL SMFHPRPFIK
     TRFAPQGSVA CIRAISDFYY DIVFRIHAEF QLNEPPNFPF WFSPGQFTGN IVISKDAAHV
     RHFKLFVPNN RTLNVDMEWL YGASESSNME VDIGYLPQME IESLGPSIPS TIYDENGNIM
     ESRNAEGEAI EFVFEDINWQ SEMTFEEAAR KLEVTMYPFK RVSYYPFPEA FDRALAEKKL
     VHSVLLWGAL DDQSCUGSGR TLRETVLESL PVLALLNESF ISTWSLVKEL EELQSNKDSY
     ATFASLHLEK YNFPVEMMIC LPNGTVVHHI NANYFLDITS LKPDEVETNL FSFSDGVEDL
     STVTYIKFLK EGLEKAKPFL HS