SELPA_DANRE
ID SELPA_DANRE Reviewed; 367 AA.
AC Q98SV1;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 3.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Selenoprotein Pa;
DE Short=zSelPa;
DE Flags: Precursor;
GN Name=sepp1a;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000312|EMBL:AAG53688.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RX PubMed=11168591; DOI=10.1046/j.1365-2443.2000.00392.x;
RA Kryukov G.V., Gladyshev V.N.;
RT "Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and
RT expression of a protein containing 17 selenocysteine residues.";
RL Genes Cells 5:1049-1060(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retina;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Might be responsible for some of the extracellular
CC antioxidant defense properties of selenium or might be involved in the
CC transport of selenium. {ECO:0000250|UniProtKB:P49908}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11168591}.
CC -!- SIMILARITY: Belongs to the selenoprotein P family. {ECO:0000305}.
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DR EMBL; AF322071; AAG53688.1; -; mRNA.
DR EMBL; BC059656; AAH59656.1; -; mRNA.
DR STRING; 7955.ENSDARP00000116562; -.
DR PaxDb; Q98SV1; -.
DR ZFIN; ZDB-GENE-030311-1; selenop.
DR eggNOG; ENOG502QWRU; Eukaryota.
DR InParanoid; Q98SV1; -.
DR PhylomeDB; Q98SV1; -.
DR Reactome; R-DRE-114608; Platelet degranulation.
DR PRO; PR:Q98SV1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0008430; F:selenium binding; IBA:GO_Central.
DR GO; GO:0001887; P:selenium compound metabolic process; IDA:ZFIN.
DR InterPro; IPR007671; Selenoprotein-P_N.
DR InterPro; IPR007672; SelP_C.
DR InterPro; IPR037941; SeP.
DR PANTHER; PTHR10105; PTHR10105; 1.
DR Pfam; PF04593; SelP_C; 1.
DR Pfam; PF04592; SelP_N; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Reference proteome; Secreted; Selenium; Selenocysteine;
KW Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..367
FT /note="Selenoprotein Pa"
FT /id="PRO_0000022300"
FT REGION 191..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..236
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_STD 59
FT /note="Selenocysteine"
FT /evidence="ECO:0000303|PubMed:11168591"
FT NON_STD 267
FT /note="Selenocysteine"
FT /evidence="ECO:0000303|PubMed:11168591"
FT NON_STD 273
FT /note="Selenocysteine"
FT /evidence="ECO:0000303|PubMed:11168591"
FT NON_STD 279
FT /note="Selenocysteine"
FT /evidence="ECO:0000303|PubMed:11168591"
FT NON_STD 290
FT /note="Selenocysteine"
FT /evidence="ECO:0000303|PubMed:11168591"
FT NON_STD 292
FT /note="Selenocysteine"
FT /evidence="ECO:0000303|PubMed:11168591"
FT NON_STD 294
FT /note="Selenocysteine"
FT /evidence="ECO:0000303|PubMed:11168591"
FT NON_STD 310
FT /note="Selenocysteine"
FT /evidence="ECO:0000303|PubMed:11168591"
FT NON_STD 320
FT /note="Selenocysteine"
FT /evidence="ECO:0000303|PubMed:11168591"
FT NON_STD 322
FT /note="Selenocysteine"
FT /evidence="ECO:0000303|PubMed:11168591"
FT NON_STD 336
FT /note="Selenocysteine"
FT /evidence="ECO:0000303|PubMed:11168591"
FT NON_STD 338
FT /note="Selenocysteine"
FT /evidence="ECO:0000303|PubMed:11168591"
FT NON_STD 346
FT /note="Selenocysteine"
FT /evidence="ECO:0000303|PubMed:11168591"
FT NON_STD 353
FT /note="Selenocysteine"
FT /evidence="ECO:0000303|PubMed:11168591"
FT NON_STD 355
FT /note="Selenocysteine"
FT /evidence="ECO:0000303|PubMed:11168591"
FT NON_STD 362
FT /note="Selenocysteine"
FT /evidence="ECO:0000303|PubMed:11168591"
FT NON_STD 364
FT /note="Selenocysteine"
FT /evidence="ECO:0000303|PubMed:11168591"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 367 AA; 41968 MW; 5CFF2C2D5DA39097 CRC64;
MWKALSLTLA LCLLVGCSAE SETEGARCKL PPEWKVGDVE PMKNALGQVT VVAYLQASUL
FCLEQASKLN DLLLKLENQG YPNIAYMVVN NREERSQRLH HLLQERLLNI TLYAQDLSQP
DAWQAVNAEK DDILVYDRCG RLTYHLSLPY TILSHPHVEE AIKHTYCDRI CGECSLESSA
QLEECKKATE EVNKPVEEEP RQDHGHHEHG HHEHQGEAER HRHGHHHPHH HHHHHRGQQQ
VDVDQQVLSQ VDFGQVAVET PMMKRPUAKH SRUKVQYSUQ QGADSPVASU CUHURQLFGG
EGNGRVAGLU HCDEPLPASU PUQGLKEQDN HIKETUQURP APPAEUELSQ PTUVUPAGDA
TUGURKK
