ID   SELP_SV40               Reviewed;          23 AA.
AC   P0C6L2; Q04240; Q9IVA6;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   02-JUN-2021, entry version 28.
DE   RecName: Full=SV40 early leader protein;
DE            Short=SELP;
OS   Simian virus 40 (SV40).
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Sepolyvirales; Polyomaviridae; Betapolyomavirus.
OX   NCBI_TaxID=1891767;
OH   NCBI_TaxID=9539; Macaca (macaques).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=205947; DOI=10.1126/science.205947;
RA   Reddy V.B., Thimmappaya B., Dhar R., Subramanian K.N., Zain B.S., Pan J.,
RA   Ghosh P.K., Celma M.L., Weissman S.M.;
RT   "The genome of simian virus 40.";
RL   Science 200:494-502(1978).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=776;
RX   PubMed=205802; DOI=10.1038/273113a0;
RA   Fiers W., Contreras R., Haegeman G., Rogiers R., van de Voorde A.,
RA   van Heuverswyn H., van Herreweghe J., Volckaert G., Ysebaert M.;
RT   "Complete nucleotide sequence of SV40 DNA.";
RL   Nature 273:113-120(1978).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=202398; DOI=10.1016/0092-8674(78)90147-2;
RA   Tjian R.;
RT   "The binding site on SV40 DNA for a T antigen-related protein.";
RL   Cell 13:165-179(1978).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=232871; DOI=10.1007/978-3-642-67344-3_3;
RA   Lebowitz P., Weissman S.M.;
RT   "Organization and transcription of the simian virus 40 genome.";
RL   Curr. Top. Microbiol. Immunol. 87:43-172(1979).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6254000; DOI=10.1073/pnas.77.7.3898;
RA   Gluzman Y., Sambrook J.F., Frisque R.J.;
RT   "Expression of early genes of origin-defective mutants of simian virus
RT   40.";
RL   Proc. Natl. Acad. Sci. U.S.A. 77:3898-3902(1980).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6258090; DOI=10.1038/289810a0;
RA   McKay R., DiMaio D.;
RT   "Binding of an SV40 T antigen-related protein to the DNA of SV40 regulatory
RT   mutants.";
RL   Nature 289:810-813(1981).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6269743; DOI=10.1016/0092-8674(81)90056-8;
RA   Myers R.M., Rio D.C., Robbins A.K., Tjian R.;
RT   "SV40 gene expression is modulated by the cooperative binding of T antigen
RT   to DNA.";
RL   Cell 25:373-384(1981).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=4A;
RA   Hubner R.K.P.;
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PML-1a, PML-1b, and PML-1c;
RA   Hubner R., Van Marck E.;
RL   Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   FUNCTION.
RX   PubMed=3028644; DOI=10.1016/0092-8674(87)90242-x;
RA   Khalili K., Brady J., Khoury G.;
RT   "Translational regulation of SV40 early mRNA defines a new viral protein.";
RL   Cell 48:639-645(1987).
CC   -!- FUNCTION: May play a role in the lytic cycle.
CC       {ECO:0000269|PubMed:3028644}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing, Alternative initiation; Named isoforms=4;
CC       Name=SELP;
CC         IsoId=P0C6L2-1; Sequence=Displayed;
CC       Name=Large T antigen;
CC         IsoId=P03070-1; Sequence=External;
CC       Name=Small t antigen;
CC         IsoId=P03081-1; Sequence=External;
CC       Name=17kT antigen;
CC         IsoId=P03070-2; Sequence=External;
CC   -!- MISCELLANEOUS: [Isoform SELP]: Produced by alternative initiation.
CC   -!- SIMILARITY: Belongs to the polyomavirus early leader protein family.
CC       {ECO:0000305}.
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DR   EMBL; J02400; AAB59919.1; -; Genomic_DNA.
DR   EMBL; AJ276576; CAB82890.1; -; Genomic_DNA.
DR   EMBL; AJ430321; CAD23041.1; -; Genomic_DNA.
DR   EMBL; AJ430322; CAD23042.1; -; Genomic_DNA.
DR   EMBL; AJ430323; CAD23043.1; -; Genomic_DNA.
DR   RefSeq; YP_003708377.1; NC_001669.1.
DR   Proteomes; UP000007705; Genome.
PE   3: Inferred from homology;
KW   Alternative initiation; Alternative splicing; Reference proteome.
FT   CHAIN           1..23
FT                   /note="SV40 early leader protein"
FT                   /id="PRO_0000355200"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   23 AA;  2705 MW;  0FA3C80E15ED0C93 CRC64;
     MQRPRPPRPL SYSRSSEEAF LEA