ID   SELSA_XENLA             Reviewed;         193 AA.
AC   Q6AZH0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Selenoprotein S A;
DE            Short=SelS A;
DE   AltName: Full=VCP-interacting membrane protein;
GN   Name=vimp-a; Synonyms=sels-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the degradation process of misfolded endoplasmic
CC       reticulum (ER) luminal proteins. Participates in the transfer of
CC       misfolded proteins from the ER to the cytosol, where they are destroyed
CC       by the proteasome in a ubiquitin-dependent manner (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the selenoprotein S family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH78025.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC078025; AAH78025.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001087125.2; NM_001093656.2.
DR   DNASU; 447014; -.
DR   GeneID; 447014; -.
DR   KEGG; xla:447014; -.
DR   CTD; 447014; -.
DR   Xenbase; XB-GENE-6254582; selenos.L.
DR   OrthoDB; 1489479at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 447014; Expressed in pancreas and 19 other tissues.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   InterPro; IPR009703; Selenoprotein_S.
DR   PANTHER; PTHR28621; PTHR28621; 1.
DR   Pfam; PF06936; Selenoprotein_S; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Selenocysteine; Transmembrane; Transmembrane helix.
FT   CHAIN           1..193
FT                   /note="Selenoprotein S A"
FT                   /id="PRO_0000318652"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          125..193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..154
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_STD         192
FT                   /note="Selenocysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   193 AA;  21392 MW;  862479DAA0851EC6 CRC64;
     MELGNQPGPG NRPEIELEWY QYVQNTVGWA LASYGWYILF GCIILYFLIQ KLSANFTRAG
     ASTHTTVTDP DEIVRRQEAV TAARMRMQEE LNAQAELYKQ KQVQLQEEKR RRNIETWDRM
     QEGKSSKVAC RLGQDASPST SASSSPSTSS SAPKPKPERK PLRGSGYNPL TGDGGSTCAW
     RPGRRGPSSG GUG