ID   SELSB_XENLA             Reviewed;         188 AA.
AC   Q68EU0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Selenoprotein S B;
DE            Short=SelS B;
DE   AltName: Full=VCP-interacting membrane protein;
GN   Name=vimp-b; Synonyms=sels-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the degradation process of misfolded endoplasmic
CC       reticulum (ER) luminal proteins. Participates in the transfer of
CC       misfolded proteins from the ER to the cytosol, where they are destroyed
CC       by the proteasome in a ubiquitin-dependent manner (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the selenoprotein S family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH80110.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC080110; AAH80110.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001087566.2; NM_001094097.2.
DR   DNASU; 447390; -.
DR   GeneID; 447390; -.
DR   KEGG; xla:447390; -.
DR   CTD; 447390; -.
DR   Xenbase; XB-GENE-1007241; selenos.S.
DR   OrthoDB; 1489479at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 447390; Expressed in pancreas and 19 other tissues.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   InterPro; IPR009703; Selenoprotein_S.
DR   PANTHER; PTHR28621; PTHR28621; 1.
DR   Pfam; PF06936; Selenoprotein_S; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Selenocysteine; Transmembrane; Transmembrane helix.
FT   CHAIN           1..188
FT                   /note="Selenoprotein S B"
FT                   /id="PRO_0000318653"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          128..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..149
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_STD         187
FT                   /note="Selenocysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   188 AA;  20972 MW;  C2DADCADB818F4E8 CRC64;
     MELGNQPGQG NRPEIELEWY QYLQNTVGEA LSNYGWYILL GCIVIYFLIQ KLSANFTRAV
     ASTRTTVTDP DEIVRRQEAV AAARMRMQVE LNAQAELYKQ KQVQLQEEKR RRNIETWDRM
     QEGKSSKVGC RLVQDASPRT STSSSAPKPK PESRPLRDSG YNPLTGGGGG TCAWRPGRRG
     PSSGGSUG