ID   SELS_DANRE              Reviewed;         190 AA.
AC   Q0VFV6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Selenoprotein S;
DE            Short=SelS;
DE   AltName: Full=VCP-interacting membrane protein;
GN   Name=vimp; Synonyms=sels; ORFNames=zgc:136970;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the degradation process of misfolded endoplasmic
CC       reticulum (ER) luminal proteins. Participates in the transfer of
CC       misfolded proteins from the ER to the cytosol, where they are destroyed
CC       by the proteasome in a ubiquitin-dependent manner (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the selenoprotein S family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI18686.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAI18686.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC118685; AAI18686.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001038799.2; NM_001045334.3.
DR   STRING; 7955.ENSDARP00000079033; -.
DR   PaxDb; Q0VFV6; -.
DR   Ensembl; ENSDART00000084598; ENSDARP00000079033; ENSDARG00000070097.
DR   GeneID; 735249; -.
DR   KEGG; dre:735249; -.
DR   CTD; 55829; -.
DR   ZFIN; ZDB-GENE-060804-1; selenos.
DR   eggNOG; ENOG502RXYU; Eukaryota.
DR   GeneTree; ENSGT00940000166109; -.
DR   InParanoid; Q0VFV6; -.
DR   OMA; LSLYGWY; -.
DR   OrthoDB; 1489479at2759; -.
DR   PhylomeDB; Q0VFV6; -.
DR   TreeFam; TF329454; -.
DR   PRO; PR:Q0VFV6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000070097; Expressed in swim bladder and 26 other tissues.
DR   GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
DR   GO; GO:0036513; C:Derlin-1 retrotranslocation complex; IBA:GO_Central.
DR   GO; GO:0036502; C:Derlin-1-VIMP complex; IBA:GO_Central.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central.
DR   GO; GO:0030970; P:retrograde protein transport, ER to cytosol; IBA:GO_Central.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   InterPro; IPR009703; Selenoprotein_S.
DR   PANTHER; PTHR28621; PTHR28621; 1.
DR   Pfam; PF06936; Selenoprotein_S; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Selenocysteine; Transmembrane; Transmembrane helix.
FT   CHAIN           1..190
FT                   /note="Selenoprotein S"
FT                   /id="PRO_0000318651"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          60..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..124
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..148
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_STD         189
FT                   /note="Selenocysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   190 AA;  21201 MW;  12D61C821A44009B CRC64;
     MEAEDGARVR NEDVPPQNQD LSFLQPSVTA FMSEYGWYLL FGCVGVYLLI QHLRKSRSST
     QTRSSSGSAE AHDVGSVVRR QEALEASRRR MQEEQDARAA EFREKQRMLE EEKRRQKIEM
     WDSMQEGKSY KGSAKVAQQN TEEAASSSSL RPKTEKKPLR SSGYSPLSGD AGGSCSWRPG
     RRGPSAGGUG