ID   SELS_XENTR              Reviewed;         189 AA.
AC   Q5I030;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Selenoprotein S;
DE            Short=SelS;
DE   AltName: Full=VCP-interacting membrane protein;
GN   Name=vimp; Synonyms=sels; ORFNames=TNeu072i15.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the degradation process of misfolded endoplasmic
CC       reticulum (ER) luminal proteins. Participates in the transfer of
CC       misfolded proteins from the ER to the cytosol, where they are destroyed
CC       by the proteasome in a ubiquitin-dependent manner (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the selenoprotein S family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH88768.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC       Sequence=CAJ83287.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR760118; CAJ83287.1; ALT_SEQ; mRNA.
DR   EMBL; BC088768; AAH88768.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001011476.2; NM_001011476.2.
DR   STRING; 8364.ENSXETP00000001095; -.
DR   PRIDE; Q5I030; -.
DR   GeneID; 496967; -.
DR   KEGG; xtr:496967; -.
DR   CTD; 55829; -.
DR   Xenbase; XB-GENE-1007235; selenos.
DR   InParanoid; Q5I030; -.
DR   OrthoDB; 1489479at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000027997; Expressed in liver and 14 other tissues.
DR   ExpressionAtlas; Q5I030; differential.
DR   GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
DR   GO; GO:0036513; C:Derlin-1 retrotranslocation complex; IBA:GO_Central.
DR   GO; GO:0036502; C:Derlin-1-VIMP complex; IBA:GO_Central.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central.
DR   GO; GO:0030970; P:retrograde protein transport, ER to cytosol; IBA:GO_Central.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   InterPro; IPR009703; Selenoprotein_S.
DR   PANTHER; PTHR28621; PTHR28621; 1.
DR   Pfam; PF06936; Selenoprotein_S; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Selenocysteine; Transmembrane; Transmembrane helix.
FT   CHAIN           1..189
FT                   /note="Selenoprotein S"
FT                   /id="PRO_0000318654"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          125..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..147
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_STD         188
FT                   /note="Selenocysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   189 AA;  21160 MW;  7BE4A88569724B12 CRC64;
     MELGNQPGPG NRPEIELEWY QYLQNTVGVV LSSYGWYILL GCILIYLLIQ KLPQNFTRAG
     TSNHSTVTDP DEIVRRQEAV TAARLRMQEE LNAQAELYKQ KQVQLQEEKR QRNIETWDRM
     KEGKSSKVAC RLGQEPSPST STSAATKPKQ EKQERKTLRG SGYNPLTGDG GGTCAWRPGR
     RGPSSGGUG