ID   SELT2_DANRE             Reviewed;         210 AA.
AC   Q502K9; Q802G4;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 3.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Selenoprotein T2 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=selenot2 {ECO:0000305};
GN   Synonyms=selt2 {ECO:0000312|ZFIN:ZDB-GENE-030411-4},
GN   sept2 {ECO:0000312|ZFIN:ZDB-GENE-030411-4}; ORFNames=zgc:112046;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAH95658.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium {ECO:0000312|EMBL:AAH95658.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305, ECO:0000312|EMBL:AAO86702.1}
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-173, AND TISSUE SPECIFICITY.
RC   TISSUE=Kidney {ECO:0000269|PubMed:12915322};
RX   PubMed=12915322; DOI=10.1016/s1567-133x(03)00054-1;
RA   Thisse C., Degrave A., Kryukov G.V., Gladyshev V.N., Obrecht-Pflumio S.,
RA   Krol A., Thisse B., Lescure A.;
RT   "Spatial and temporal expression patterns of selenoprotein genes during
RT   embryogenesis in zebrafish.";
RL   Gene Expr. Patterns 3:525-532(2003).
CC   -!- TISSUE SPECIFICITY: Widely expressed in the embryo.
CC       {ECO:0000269|PubMed:12915322}.
CC   -!- PTM: May contain a selenide-sulfide bond between Cys-62 and Sec-65.
CC       This bond is speculated to serve as redox-active pair (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SelWTH family. Selenoprotein T subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH95658.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC095658; AAH95658.1; ALT_SEQ; mRNA.
DR   EMBL; AY216588; AAO86702.1; -; mRNA.
DR   RefSeq; NP_001091957.2; NM_001098487.2.
DR   STRING; 7955.ENSDARP00000114858; -.
DR   PaxDb; Q502K9; -.
DR   Ensembl; ENSDART00000143486; ENSDARP00000114858; ENSDARG00000023220.
DR   GeneID; 352917; -.
DR   KEGG; dre:352917; -.
DR   CTD; 352917; -.
DR   ZFIN; ZDB-GENE-030411-4; selenot2.
DR   eggNOG; KOG3286; Eukaryota.
DR   GeneTree; ENSGT00390000011725; -.
DR   HOGENOM; CLU_113870_1_0_1; -.
DR   InParanoid; Q502K9; -.
DR   OMA; PPGLNYY; -.
DR   OrthoDB; 1542197at2759; -.
DR   PhylomeDB; Q502K9; -.
DR   TreeFam; TF321235; -.
DR   PRO; PR:Q502K9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 14.
DR   Bgee; ENSDARG00000023220; Expressed in somite and 27 other tissues.
DR   ExpressionAtlas; Q502K9; baseline and differential.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0004791; F:thioredoxin-disulfide reductase activity; IBA:GO_Central.
DR   GO; GO:0045454; P:cell redox homeostasis; IBA:GO_Central.
DR   InterPro; IPR011893; Selenoprotein_Rdx-typ.
DR   InterPro; IPR019389; Selenoprotein_T.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR13544; PTHR13544; 1.
DR   Pfam; PF10262; Rdx; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR02174; CXXU_selWTH; 1.
PE   2: Evidence at transcript level;
KW   Redox-active center; Reference proteome; Selenocysteine; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..210
FT                   /note="Selenoprotein T2"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000252043"
FT   NON_STD         65
FT                   /note="Selenocysteine"
FT                   /evidence="ECO:0000312|EMBL:AAO86702.1"
FT   CROSSLNK        62..65
FT                   /note="Cysteinyl-selenocysteine (Cys-Sec)"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        40
FT                   /note="D -> N (in Ref. 2; AAO86702)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   210 AA;  24175 MW;  D7308C9B5B101545 CRC64;
     MAEYSQTGIL TALLLFTVVT VKDIYVGRNS VTQQENTGPD INTQRQNKHT FYTGPVLKFQ
     YCISUGYSKV FQEYSRSISQ LYPDIRIEGD NYPPKPINKY LGNFLSYFKL LAIALIVTGQ
     NPFQMFGMNT PRIWAWGQEN KIFSCLMAFF ISNMLETHFL STGAFEITLN DIPIWSKLQS
     GYVPNIQELF QILDNHLKMN QADKMNFPSP