SELTA_DANRE
ID SELTA_DANRE Reviewed; 193 AA.
AC Q802F2; Q0Z8S3;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 3.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Thioredoxin reductase-like selenoprotein T1a {ECO:0000305};
DE EC=1.8.1.9 {ECO:0000250|UniProtKB:Q1H5H1};
DE Flags: Precursor;
GN Name=selenot1a {ECO:0000305};
GN Synonyms=selt1a {ECO:0000312|ZFIN:ZDB-GENE-030327-6},
GN sept1a {ECO:0000312|ZFIN:ZDB-GENE-030327-6};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAO65273.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Embryo {ECO:0000269|PubMed:12915322};
RX PubMed=12915322; DOI=10.1016/s1567-133x(03)00054-1;
RA Thisse C., Degrave A., Kryukov G.V., Gladyshev V.N., Obrecht-Pflumio S.,
RA Krol A., Thisse B., Lescure A.;
RT "Spatial and temporal expression patterns of selenoprotein genes during
RT embryogenesis in zebrafish.";
RL Gene Expr. Patterns 3:525-532(2003).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAH54578.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney {ECO:0000312|EMBL:AAH54578.2};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAH54578.2}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-174.
RC TISSUE=Gastrula {ECO:0000305, ECO:0000312|EMBL:ABG54379.1};
RA Frabetti F., Casadei R., Vitale L., Lenzi L., Canaider S., Facchin F.,
RA Carinci P., Zannotti M., Strippoli P.;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Selenoprotein with thioredoxin reductase-like oxidoreductase
CC activity. {ECO:0000250|UniProtKB:Q1H5H1}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide +
CC H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA-
CC COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9;
CC Evidence={ECO:0000250|UniProtKB:Q1H5H1};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q1H5H1}; Single-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in embryonic olfactory vesicles and the
CC photoreceptor cell layer of the embryonic retina. Low level in
CC embryonic epiphysis. {ECO:0000269|PubMed:12915322}.
CC -!- PTM: May contain a selenide-sulfide bond between Cys-44 and Sec-47.
CC This bond is speculated to serve as redox-active pair (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SelWTH family. Selenoprotein T subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH54578.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAO65273.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=ABG54379.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY221264; AAO65273.1; ALT_INIT; mRNA.
DR EMBL; BC054578; AAH54578.2; ALT_INIT; mRNA.
DR EMBL; DQ660904; ABG54379.1; ALT_INIT; mRNA.
DR RefSeq; NP_840075.2; NM_178290.6.
DR STRING; 7955.ENSDARP00000075657; -.
DR PaxDb; Q802F2; -.
DR Ensembl; ENSDART00000165712; ENSDARP00000136996; ENSDARG00000058354.
DR GeneID; 352919; -.
DR KEGG; dre:352919; -.
DR CTD; 352919; -.
DR ZFIN; ZDB-GENE-030327-6; selenot1a.
DR eggNOG; KOG3286; Eukaryota.
DR GeneTree; ENSGT00390000011725; -.
DR InParanoid; Q802F2; -.
DR OMA; CISXGYR; -.
DR OrthoDB; 1542197at2759; -.
DR PhylomeDB; Q802F2; -.
DR PRO; PR:Q802F2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 2.
DR Bgee; ENSDARG00000058354; Expressed in intestine and 47 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004791; F:thioredoxin-disulfide reductase activity; IBA:GO_Central.
DR GO; GO:0045454; P:cell redox homeostasis; IBA:GO_Central.
DR InterPro; IPR011893; Selenoprotein_Rdx-typ.
DR InterPro; IPR019389; Selenoprotein_T.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR13544; PTHR13544; 1.
DR Pfam; PF10262; Rdx; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR TIGRFAMs; TIGR02174; CXXU_selWTH; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; NADP; Oxidoreductase; Redox-active center;
KW Reference proteome; Selenocysteine; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..193
FT /note="Thioredoxin reductase-like selenoprotein T1a"
FT /evidence="ECO:0000255"
FT /id="PRO_0000252041"
FT TRANSMEM 83..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT NON_STD 47
FT /note="Selenocysteine"
FT /evidence="ECO:0000312|EMBL:AAO65273.1"
FT CROSSLNK 44..47
FT /note="Cysteinyl-selenocysteine (Cys-Sec)"
FT /evidence="ECO:0000255"
SQ SEQUENCE 193 AA; 22261 MW; DBAA422C92D4E7EA CRC64;
MRWLPFSALL LWALCLHSAS ADNNGVKKMK MQFATGPLLK FQICVSUGYK RVFEEYTQAL
YQRYPDIRIE GENYLPLPLY RHIASFLSMF KLLLIGVIIL GKDPFALCGM QAPGIWVWSQ
ENKIYACMMV FFFSNMIENQ CMSTGAFEIT LNDVPVWSKL ESGHLPSMQQ LVQILENEMK
MSMHMDTLPP HQS
