SELT_BOVIN
ID SELT_BOVIN Reviewed; 195 AA.
AC A6QP01;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Thioredoxin reductase-like selenoprotein T {ECO:0000305};
DE Short=SelT {ECO:0000250|UniProtKB:P62341};
DE EC=1.8.1.9 {ECO:0000250|UniProtKB:Q1H5H1};
DE Flags: Precursor;
GN Name=SELENOT {ECO:0000250|UniProtKB:P62341};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Basal ganglia;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Selenoprotein with thioredoxin reductase-like oxidoreductase
CC activity (By similarity). Protects dopaminergic neurons against
CC oxidative stress and cell death (By similarity). Involved in
CC ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion
CC (By similarity). Plays a role in fibroblast anchorage and redox
CC regulation (By similarity). In gastric smooth muscle, modulates the
CC contraction processes through the regulation of calcium release and
CC MYLK activation (By similarity). In pancreatic islets, involved in the
CC control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-
CC induced insulin secretion (By similarity).
CC {ECO:0000250|UniProtKB:P62341, ECO:0000250|UniProtKB:P62342,
CC ECO:0000250|UniProtKB:Q1H5H1}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide +
CC H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA-
CC COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9;
CC Evidence={ECO:0000250|UniProtKB:Q1H5H1};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q1H5H1}; Single-pass membrane protein
CC {ECO:0000255}.
CC -!- PTM: May contain a selenide-sulfide bond between Cys-46 and Sec-49.
CC This bond is speculated to serve as redox-active pair (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SelWTH family. Selenoprotein T subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI49083.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; BC149082; AAI49083.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001096573.2; NM_001103103.2.
DR STRING; 9913.ENSBTAP00000042037; -.
DR PaxDb; A6QP01; -.
DR Ensembl; ENSBTAT00000044548; ENSBTAP00000042037; ENSBTAG00000031435.
DR GeneID; 783831; -.
DR KEGG; bta:783831; -.
DR CTD; 51714; -.
DR VEuPathDB; HostDB:ENSBTAG00000031435; -.
DR VGNC; VGNC:53604; SELENOT.
DR eggNOG; KOG3286; Eukaryota.
DR GeneTree; ENSGT00390000011725; -.
DR InParanoid; A6QP01; -.
DR OMA; CISXGYR; -.
DR OrthoDB; 1150650at2759; -.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000031435; Expressed in prostate gland and 106 other tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004791; F:thioredoxin-disulfide reductase activity; ISS:UniProtKB.
DR GO; GO:0045454; P:cell redox homeostasis; ISS:UniProtKB.
DR GO; GO:0098869; P:cellular oxidant detoxification; ISS:UniProtKB.
DR GO; GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
DR GO; GO:0035773; P:insulin secretion involved in cellular response to glucose stimulus; ISS:UniProtKB.
DR GO; GO:0031016; P:pancreas development; ISS:UniProtKB.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISS:UniProtKB.
DR GO; GO:0060124; P:positive regulation of growth hormone secretion; ISS:UniProtKB.
DR GO; GO:0009749; P:response to glucose; ISS:UniProtKB.
DR InterPro; IPR011893; Selenoprotein_Rdx-typ.
DR InterPro; IPR019389; Selenoprotein_T.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR13544; PTHR13544; 1.
DR Pfam; PF10262; Rdx; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR TIGRFAMs; TIGR02174; CXXU_selWTH; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; NADP; Oxidoreductase; Redox-active center;
KW Reference proteome; Selenocysteine; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..195
FT /note="Thioredoxin reductase-like selenoprotein T"
FT /id="PRO_0000318656"
FT TRANSMEM 85..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT NON_STD 49
FT /note="Selenocysteine"
FT CROSSLNK 46..49
FT /note="Cysteinyl-selenocysteine (Cys-Sec)"
FT /evidence="ECO:0000255"
SQ SEQUENCE 195 AA; 22248 MW; 9F68E7A4C3A083AE CRC64;
MRLLLLLLVA ASAVVRSDAS ANLGGVPGKR LKMQYATGPL LKFQICVSUG YRRVFEEYMR
VISQRYPDIR IEGENYLPQP IYRHIASFLS VFKLVLIGLI IVGKDPFAFF GMQAPSIWQW
GQENKVYACM MVFFLSNMIE NQCMSTGAFE ITLNDVPVWS KLESGHLPSM QQLVQILDNE
MKLNVHMDSI PHHRS
