SELT_XENTR
ID SELT_XENTR Reviewed; 201 AA.
AC Q6PBD1; Q28CY0;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 3.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Thioredoxin reductase-like selenoprotein T {ECO:0000305};
DE Short=SelT {ECO:0000250|UniProtKB:P62341};
DE EC=1.8.1.9 {ECO:0000250|UniProtKB:Q1H5H1};
DE Flags: Precursor;
GN Name=selenot; Synonyms=selt {ECO:0000312|EMBL:AAH59764.1};
GN ORFNames=TNeu015n05.1 {ECO:0000312|EMBL:CAJ82619.1},
GN TTpA003b03.1 {ECO:0000312|EMBL:CAJ82896.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAJ82619.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula, and Tadpole;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305, ECO:0000312|EMBL:CAJ82619.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-201.
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH59764.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Selenoprotein with thioredoxin reductase-like oxidoreductase
CC activity. {ECO:0000250|UniProtKB:Q1H5H1}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide +
CC H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698, Rhea:RHEA-
CC COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.9;
CC Evidence={ECO:0000250|UniProtKB:Q1H5H1};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q1H5H1}; Single-pass membrane protein
CC {ECO:0000255}.
CC -!- PTM: May contain a selenide-sulfide bond between Cys-51 and Sec-54.
CC This bond is speculated to serve as redox-active pair (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SelWTH family. Selenoprotein T subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH59764.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAJ82619.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CR760355; CAJ82619.1; ALT_INIT; mRNA.
DR EMBL; CR855814; CAJ82896.1; -; mRNA.
DR EMBL; BC059764; AAH59764.1; ALT_INIT; mRNA.
DR RefSeq; NP_988868.2; NM_203537.2.
DR STRING; 8364.ENSXETP00000060967; -.
DR PaxDb; Q6PBD1; -.
DR DNASU; 394463; -.
DR GeneID; 394463; -.
DR KEGG; xtr:394463; -.
DR CTD; 51714; -.
DR Xenbase; XB-GENE-5780991; selenot.
DR eggNOG; KOG3286; Eukaryota.
DR HOGENOM; CLU_113870_2_0_1; -.
DR InParanoid; Q6PBD1; -.
DR OrthoDB; 1542197at2759; -.
DR PhylomeDB; Q6PBD1; -.
DR Proteomes; UP000008143; Chromosome 5.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000020094; Expressed in embryo and 27 other tissues.
DR ExpressionAtlas; Q6PBD1; differential.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004791; F:thioredoxin-disulfide reductase activity; ISS:UniProtKB.
DR GO; GO:0045454; P:cell redox homeostasis; ISS:UniProtKB.
DR GO; GO:0098869; P:cellular oxidant detoxification; ISS:UniProtKB.
DR GO; GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
DR GO; GO:0035773; P:insulin secretion involved in cellular response to glucose stimulus; ISS:UniProtKB.
DR GO; GO:0031016; P:pancreas development; ISS:UniProtKB.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISS:UniProtKB.
DR GO; GO:0060124; P:positive regulation of growth hormone secretion; ISS:UniProtKB.
DR GO; GO:0009749; P:response to glucose; ISS:UniProtKB.
DR InterPro; IPR011893; Selenoprotein_Rdx-typ.
DR InterPro; IPR019389; Selenoprotein_T.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR13544; PTHR13544; 1.
DR Pfam; PF10262; Rdx; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR TIGRFAMs; TIGR02174; CXXU_selWTH; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; NADP; Oxidoreductase; Redox-active center;
KW Reference proteome; Selenocysteine; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..201
FT /note="Thioredoxin reductase-like selenoprotein T"
FT /evidence="ECO:0000255"
FT /id="PRO_0000252044"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT NON_STD 54
FT /note="Selenocysteine"
FT /evidence="ECO:0000255"
FT CROSSLNK 51..54
FT /note="Cysteinyl-selenocysteine (Cys-Sec)"
FT /evidence="ECO:0000255"
FT CONFLICT 143
FT /note="M -> N (in Ref. 1; CAJ82896)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 201 AA; 22529 MW; 604B88EC17846F73 CRC64;
MARSSGPLCL LLLGGLVAGI LSGASADGNG LPSKKLKMQY TAGPLLKFQI CVSUGYRRVF
EDYMRVISQR YPDIRIEGEN YLPHPIYRNI ASFLSVFKLV LIGLIIAGKD PFAFFGMQAP
SVWQWGQENK VYACMMVFFV SNMIENQCMS TGAFEITLND VPVWSKLESG HLPSVQQLVQ
IIDNEMKLNV HMDAIPHHHR S
