ID   BGBP1_GALME             Reviewed;         490 AA.
AC   Q0E666; C0HLY9;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Beta-1,3-glucan-binding protein 1 {ECO:0000305};
DE            Short=BGBP1 {ECO:0000305};
DE   AltName: Full=Beta-1,3-glucan recognition protein {ECO:0000303|PubMed:34443685};
DE   Flags: Precursor;
GN   Name=bgrp1 {ECO:0000312|EMBL:CAK22401.1};
OS   Galleria mellonella (Greater wax moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Pyraloidea;
OC   Pyralidae; Galleriinae; Galleria.
OX   NCBI_TaxID=7137 {ECO:0000312|EMBL:CAK22401.1};
RN   [1] {ECO:0000312|EMBL:CAK22401.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Niere M., Weise C., Wernig-Pohl U., Goetz P.;
RT   "Identification of a beta-1,3-glucan recognition protein from the hemolymph
RT   of Galleria mellonella larvae.";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 20-39, FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=34443685; DOI=10.3390/molecules26165097;
RA   Staczek S., Zdybicka-Barabas A., Wojda I., Wiater A., Mak P., Suder P.,
RA   Skrzypiec K., Cytrynska M.;
RT   "Fungal alpha-1,3-Glucan as a New Pathogen-Associated Molecular Pattern in
RT   the Insect Model Host Galleria mellonella.";
RL   Molecules 26:5097-5097(2021).
CC   -!- FUNCTION: Plays a role in the recognition of invading microorganisms
CC       activating the phenoloxidase cascade (By similarity). Binds
CC       specifically to beta-1,3-glucan (By similarity). Binds the Aspergillus
CC       niger cell wall component alpha-1,3-glucan, a fungal pathogen-
CC       associated molecular pattern (PAMP) that activates the host immune
CC       response (PubMed:34443685). {ECO:0000250|UniProtKB:Q9NL89,
CC       ECO:0000269|PubMed:34443685}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q9NL89}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34443685}.
CC       Note=Secreted in the hemolymph. {ECO:0000269|PubMed:34443685}.
CC   -!- TISSUE SPECIFICITY: Hemolymph. {ECO:0000269|PubMed:34443685}.
CC   -!- SIMILARITY: Belongs to the insect beta-1,3-glucan binding protein
CC       family. {ECO:0000305}.
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DR   EMBL; AM265582; CAK22401.1; -; mRNA.
DR   CAZy; CBM39; Carbohydrate-Binding Module Family 39.
DR   CAZy; GH16; Glycoside Hydrolase Family 16.
DR   Proteomes; UP000504614; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   CDD; cd02179; GH16_beta_GRP; 1.
DR   Gene3D; 2.60.40.2140; -; 1.
DR   InterPro; IPR031756; BGBP_N.
DR   InterPro; IPR043030; BGBP_N_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000757; GH16.
DR   InterPro; IPR035806; GH16_GRP_C.
DR   Pfam; PF15886; CBM39; 1.
DR   Pfam; PF00722; Glyco_hydro_16; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS51969; CBM39; 1.
DR   PROSITE; PS51762; GH16_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Immunity; Innate immunity;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..490
FT                   /note="Beta-1,3-glucan-binding protein 1"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5004171107"
FT   DOMAIN          20..119
FT                   /note="CBM39"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01314"
FT   DOMAIN          152..490
FT                   /note="GH16"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01098"
FT   CARBOHYD        372
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   490 AA;  55395 MW;  46D3A6133E56B6B3 CRC64;
     MYKQTVVIFL LCFFICVSCY EVPPAKLEAI WPKGLRVSLP DDGYSLFAFH GKLNEEMEGL
     EAGHWSRDIT KSKGGRWTFN DKQAKLKIGD KIYFWTYVIK EGLGYRQDNG EWTVTGYVDE
     AGNPVAPTSQ PDAVVTEPPA AITPATAIVT NPPTSQNTYP CEISVSMVSV PGFVCKGQLL
     FEDNFNKGID KGNIWTTENM FPGEPDYPFN VYLYDNVHVR DGKLIITPTT LESKYGEDYV
     RQQLDLTQRC TGTIGTADCT RVASGPIILP PVITSKINTK NRFSFKYGRV EVRARMPTGD
     WLIPEILLEP RDRIYGIHSY ASGLLRVACV KGNVEYSKTL YGGPILCDSE PYRNVNLKQK
     IGFDHWNKDF HNYTLEWRPD GISLFVDGEK YGDVTPPTDG FYGDAKKENV QAASQWLKGT
     SMAPLDDYFY ISIGLDVGGV HEFPDSSTKP WQNKATKAML NFWNNRDQWF PTWFKDTSSL
     QVDYVRVYAL