SELV_HUMAN
ID SELV_HUMAN Reviewed; 346 AA.
AC P59797; Q17RG5;
DT 04-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Selenoprotein V {ECO:0000303|PubMed:27645994};
DE Short=SelV {ECO:0000303|PubMed:27645994};
GN Name=SELENOV {ECO:0000303|PubMed:27645994, ECO:0000312|HGNC:HGNC:30399};
GN Synonyms=SELV {ECO:0000303|PubMed:12775843};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12775843; DOI=10.1126/science.1083516;
RA Kryukov G.V., Castellano S., Novoselov S.V., Lobanov A.V., Zehtab O.,
RA Guigo R., Gladyshev V.N.;
RT "Characterization of mammalian selenoproteomes.";
RL Science 300:1439-1443(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NOMENCLATURE.
RX PubMed=27645994; DOI=10.1074/jbc.m116.756155;
RA Gladyshev V.N., Arner E.S., Berry M.J., Brigelius-Flohe R., Bruford E.A.,
RA Burk R.F., Carlson B.A., Castellano S., Chavatte L., Conrad M.,
RA Copeland P.R., Diamond A.M., Driscoll D.M., Ferreiro A., Flohe L.,
RA Green F.R., Guigo R., Handy D.E., Hatfield D.L., Hesketh J., Hoffmann P.R.,
RA Holmgren A., Hondal R.J., Howard M.T., Huang K., Kim H.Y., Kim I.Y.,
RA Koehrle J., Krol A., Kryukov G.V., Lee B.J., Lee B.C., Lei X.G., Liu Q.,
RA Lescure A., Lobanov A.V., Loscalzo J., Maiorino M., Mariotti M.,
RA Sandeep Prabhu K., Rayman M.P., Rozovsky S., Salinas G., Schmidt E.E.,
RA Schomburg L., Schweizer U., Simonovic M., Sunde R.A., Tsuji P.A.,
RA Tweedie S., Ursini F., Whanger P.D., Zhang Y.;
RT "Selenoprotein gene nomenclature.";
RL J. Biol. Chem. 291:24036-24040(2016).
RN [4]
RP UBIQUITINATION.
RX PubMed=26138980; DOI=10.1126/science.aab0515;
RA Lin H.C., Ho S.C., Chen Y.Y., Khoo K.H., Hsu P.H., Yen H.C.;
RT "SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins produced
RT by failed UGA/Sec decoding.";
RL Science 349:91-95(2015).
CC -!- FUNCTION: May be involved in a redox-related process. {ECO:0000305}.
CC -!- INTERACTION:
CC P59797; Q92624: APPBP2; NbExp=3; IntAct=EBI-10216195, EBI-743771;
CC P59797; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-10216195, EBI-743105;
CC P59797; Q08379: GOLGA2; NbExp=3; IntAct=EBI-10216195, EBI-618309;
CC P59797; O75031: HSF2BP; NbExp=3; IntAct=EBI-10216195, EBI-7116203;
CC P59797; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-10216195, EBI-741158;
CC P59797; Q13526: PIN1; NbExp=3; IntAct=EBI-10216195, EBI-714158;
CC P59797; P86479: PRR20C; NbExp=3; IntAct=EBI-10216195, EBI-10172814;
CC P59797; Q2TAL8: QRICH1; NbExp=3; IntAct=EBI-10216195, EBI-2798044;
CC P59797; Q8NF64-2: ZMIZ2; NbExp=3; IntAct=EBI-10216195, EBI-10182121;
CC P59797; Q96E35: ZMYND19; NbExp=6; IntAct=EBI-10216195, EBI-746595;
CC -!- TISSUE SPECIFICITY: Testis specific. {ECO:0000269|PubMed:12775843}.
CC -!- PTM: Truncated SELENOV proteins produced by failed UGA/Sec decoding are
CC ubiquitinated by the CRL2(APPBP2) complex, which recognizes the glycine
CC (Gly) at the C-terminus of truncated SELENOV proteins.
CC {ECO:0000269|PubMed:26138980}.
CC -!- SIMILARITY: Belongs to the SelWTH family. {ECO:0000305}.
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DR EMBL; AY324825; AAP85542.1; -; mRNA.
DR EMBL; BC117331; AAI17332.1; -; mRNA.
DR CCDS; CCDS54266.1; -.
DR RefSeq; NP_874363.1; NM_182704.1.
DR BioGRID; 131519; 11.
DR IntAct; P59797; 10.
DR STRING; 9606.ENSP00000333956; -.
DR iPTMnet; P59797; -.
DR PhosphoSitePlus; P59797; -.
DR BioMuta; SELENOV; -.
DR DMDM; 190358771; -.
DR MassIVE; P59797; -.
DR PaxDb; P59797; -.
DR PeptideAtlas; P59797; -.
DR PRIDE; P59797; -.
DR Antibodypedia; 66930; 58 antibodies from 12 providers.
DR DNASU; 348303; -.
DR Ensembl; ENST00000335426.8; ENSP00000333956.4; ENSG00000186838.14.
DR GeneID; 348303; -.
DR KEGG; hsa:348303; -.
DR MANE-Select; ENST00000335426.9; ENSP00000333956.4; NM_182704.2; NP_874363.1.
DR CTD; 348303; -.
DR DisGeNET; 348303; -.
DR GeneCards; SELENOV; -.
DR HGNC; HGNC:30399; SELENOV.
DR HPA; ENSG00000186838; Tissue enriched (testis).
DR MIM; 607919; gene.
DR neXtProt; NX_P59797; -.
DR OpenTargets; ENSG00000186838; -.
DR VEuPathDB; HostDB:ENSG00000186838; -.
DR eggNOG; ENOG502S9W8; Eukaryota.
DR GeneTree; ENSGT00940000163358; -.
DR InParanoid; P59797; -.
DR OMA; HLGYDYA; -.
DR OrthoDB; 1594709at2759; -.
DR PhylomeDB; P59797; -.
DR PathwayCommons; P59797; -.
DR SignaLink; P59797; -.
DR BioGRID-ORCS; 348303; 8 hits in 1026 CRISPR screens.
DR ChiTaRS; SELENOV; human.
DR GenomeRNAi; 348303; -.
DR Pharos; P59797; Tdark.
DR PRO; PR:P59797; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P59797; protein.
DR Bgee; ENSG00000186838; Expressed in left testis and 46 other tissues.
DR ExpressionAtlas; P59797; baseline and differential.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0010269; P:response to selenium ion; IBA:GO_Central.
DR InterPro; IPR011893; Selenoprotein_Rdx-typ.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF10262; Rdx; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR TIGRFAMs; TIGR02174; CXXU_selWTH; 1.
PE 1: Evidence at protein level;
KW Redox-active center; Reference proteome; Selenocysteine; Ubl conjugation.
FT CHAIN 1..346
FT /note="Selenoprotein V"
FT /id="PRO_0000097675"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..169
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_STD 273
FT /note="Selenocysteine"
FT /evidence="ECO:0000305|PubMed:12775843"
FT CROSSLNK 270..273
FT /note="Cysteinyl-selenocysteine (Cys-Sec); redox-active"
FT /evidence="ECO:0000250"
FT VARIANT 284
FT /note="K -> R (in dbSNP:rs56149652)"
FT /id="VAR_061790"
SQ SEQUENCE 346 AA; 36800 MW; E11FEC8A4E232A28 CRC64;
MNNQARTPAP SSARTSTSVR ASTPTRTPTP LRTPTPVRTR TPIRTLTPVL TPSPAGTSPL
VLTPAPAQIP TLVPTPALAR IPRLVPPPAP AWIPTPVPTP VPVRNPTPVP TPARTLTPPV
RVPAPAPAQL LAGIRAALPV LDSYLAPALP LDPPPEPAPE LPLLPEEDPE PAPSLKLIPS
VSSEAGPAPG PLPTRTPLAA NSPGPTLDFT FRADPSAIGL ADPPIPSPVP SPILGTIPSA
ISLQNCTETF PSSSENFALD KRVLIRVTYC GLUSYSLRYI LLKKSLEQQF PNHLLFEEDR
AAQATGEFEV FVNGRLVHSK KRGDGFVNES RLQKIVSVID EEIKKR
