ID   SELW_CHICK              Reviewed;          85 AA.
AC   D0EYG3;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Selenoprotein W {ECO:0000312|EMBL:ACX47065.1};
DE            Short=SelW {ECO:0000250|UniProtKB:P63302};
GN   Name=SELENOW {ECO:0000250|UniProtKB:P63302};
GN   Synonyms=SELW {ECO:0000303|PubMed:21132387},
GN   SEPW1 {ECO:0000250|UniProtKB:P63302};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ACX47065.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC   TISSUE=Brain {ECO:0000269|PubMed:21132387};
RX   PubMed=21132387; DOI=10.1007/s11033-010-0520-5;
RA   Li J.L., Ruan H.F., Li H.X., Li S., Xu S.W., Tang Z.X.;
RT   "Molecular cloning, characterization and mRNA expression analysis of a
RT   novel selenoprotein: avian selenoprotein W from chicken.";
RL   Mol. Biol. Rep. 38:4015-4022(2011).
CC   -!- FUNCTION: Plays a role as a glutathione (GSH)-dependent antioxidant.
CC       May be involved in a redox-related process. May play a role in the
CC       myopathies of selenium deficiency (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P63301}.
CC   -!- TISSUE SPECIFICITY: Expressed ubiquitously with predominant expression
CC       in the pituitary, spinal cord, sciatic nerve, cerebral cortex, cerebral
CC       nuclei, thalamus, cerebellum, muscle, cartilage, trachea, gizzard and
CC       artery. Weakly expressed in pancreas, testis, ovary, kidney and veins.
CC       {ECO:0000269|PubMed:21132387}.
CC   -!- INDUCTION: Up-regulated by dietary selenium in cerebral tissue.
CC       {ECO:0000269|PubMed:21132387}.
CC   -!- SIMILARITY: Belongs to the SelWTH family. Selenoprotein W subfamily.
CC       {ECO:0000305}.
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DR   EMBL; GQ919055; ACX47065.1; -; mRNA.
DR   RefSeq; NP_001159799.1; NM_001166327.1.
DR   GeneID; 100310814; -.
DR   KEGG; gga:100310814; -.
DR   CTD; 6415; -.
DR   VEuPathDB; HostDB:geneid_100310814; -.
DR   InParanoid; D0EYG3; -.
DR   OrthoDB; 1594709at2759; -.
DR   PhylomeDB; D0EYG3; -.
DR   PRO; PR:D0EYG3; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016209; F:antioxidant activity; IEA:UniProtKB-KW.
DR   GO; GO:0010269; P:response to selenium ion; IBA:GO_Central.
DR   InterPro; IPR011893; Selenoprotein_Rdx-typ.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF10262; Rdx; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR02174; CXXU_selWTH; 1.
PE   2: Evidence at transcript level;
KW   Antioxidant; Cytoplasm; Redox-active center; Reference proteome;
KW   Selenocysteine.
FT   CHAIN           1..85
FT                   /note="Selenoprotein W"
FT                   /id="PRO_0000410704"
FT   NON_STD         13
FT                   /note="Selenocysteine"
FT                   /evidence="ECO:0000255"
FT   CROSSLNK        10..13
FT                   /note="Cysteinyl-selenocysteine (Cys-Sec); redox-active"
FT                   /evidence="ECO:0000250|UniProtKB:P25236"
SQ   SEQUENCE   85 AA;  9472 MW;  0FF0F6F393A1906D CRC64;
     MPLRVTVLYC GAUGYKPKYE RLRAELEKRF PGALEMRGQG TQEVTGWFEV TVGSRLVHSK
     KNGDGFVDTD AKLQRIVAAI QAALP