ID   SELW_DANRE              Reviewed;          86 AA.
AC   Q568W0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 3.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Selenoprotein W {ECO:0000250|UniProtKB:P63302};
DE            Short=SelW {ECO:0000250|UniProtKB:P63302};
GN   Name=selenow {ECO:0000250|UniProtKB:P63302}; Synonyms=sepw1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role as a glutathione (GSH)-dependent antioxidant.
CC       May be involved in a redox-related process. May play a role in the
CC       myopathies of selenium deficiency (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SelWTH family. Selenoprotein W subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC092686; AAH92686.2; -; mRNA.
DR   STRING; 7955.ENSDARP00000117583; -.
DR   PaxDb; Q568W0; -.
DR   ZFIN; ZDB-GENE-030410-5; selenow1.
DR   eggNOG; ENOG502S9W8; Eukaryota.
DR   InParanoid; Q568W0; -.
DR   PRO; PR:Q568W0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016209; F:antioxidant activity; IEA:UniProtKB-KW.
DR   GO; GO:0010269; P:response to selenium ion; IBA:GO_Central.
DR   InterPro; IPR011893; Selenoprotein_Rdx-typ.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF10262; Rdx; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR02174; CXXU_selWTH; 1.
PE   3: Inferred from homology;
KW   Antioxidant; Cytoplasm; Redox-active center; Reference proteome;
KW   Selenocysteine.
FT   CHAIN           1..86
FT                   /note="Selenoprotein W"
FT                   /id="PRO_0000318635"
FT   NON_STD         13
FT                   /note="Selenocysteine"
FT   CROSSLNK        10..13
FT                   /note="Cysteinyl-selenocysteine (Cys-Sec); redox-active"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   86 AA;  9539 MW;  11B83F6310C5F5DB CRC64;
     MTVKVHVVYC GGUGYRPKFI KLKTLLEDEF PNELEITGEG TPSTTGWLEV EVNGKLVHSK
     KNGDGFVDSD SKMQKIMTAI EQAMGK