ID   BGBP2_GALME             Reviewed;          20 AA.
AC   C0HLY6;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 1.
DT   03-AUG-2022, entry version 3.
DE   RecName: Full=Beta-1,3-glucan-binding protein 2 {ECO:0000303|PubMed:34443685};
DE            Short=BGBP {ECO:0000305};
DE   AltName: Full=Beta-1,3-glucan recognition protein {ECO:0000250|UniProtKB:Q8MU95};
DE            Short=BetaGRP {ECO:0000250|UniProtKB:Q8MU95};
DE   Flags: Fragment;
OS   Galleria mellonella (Greater wax moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Pyraloidea;
OC   Pyralidae; Galleriinae; Galleria.
OX   NCBI_TaxID=7137;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX   PubMed=34443685; DOI=10.3390/molecules26165097;
RA   Staczek S., Zdybicka-Barabas A., Wojda I., Wiater A., Mak P., Suder P.,
RA   Skrzypiec K., Cytrynska M.;
RT   "Fungal alpha-1,3-Glucan as a New Pathogen-Associated Molecular Pattern in
RT   the Insect Model Host Galleria mellonella.";
RL   Molecules 26:5097-5097(2021).
CC   -!- FUNCTION: Involved in the recognition of invading microorganisms
CC       causing their aggregation (By similarity). Activates the phenoloxidase
CC       cascade (By similarity). Binds specifically to beta-1,3-glucan (By
CC       similarity). Binds the A.niger cell wall component alpha-1,3-glucan, a
CC       fungal pathogen-associated molecular pattern (PAMP) that activates the
CC       host immune response (PubMed:34443685). {ECO:0000250|UniProtKB:Q8MU95,
CC       ECO:0000269|PubMed:34443685}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q8MU95}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34443685}.
CC       Note=Secreted in the hemolymph. {ECO:0000269|PubMed:34443685}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in last instar larvae.
CC       {ECO:0000269|PubMed:34443685}.
CC   -!- SIMILARITY: Belongs to the insect beta-1,3-glucan binding protein
CC       family. {ECO:0000305}.
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DR   Proteomes; UP000504614; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Immunity; Innate immunity; Reference proteome;
KW   Secreted.
FT   CHAIN           <1..>20
FT                   /note="Beta-1,3-glucan-binding protein 2"
FT                   /id="PRO_0000455047"
FT   NON_TER         1
FT                   /evidence="ECO:0000303|PubMed:34443685"
FT   NON_TER         20
FT                   /evidence="ECO:0000303|PubMed:34443685"
SQ   SEQUENCE   20 AA;  2188 MW;  4216007003FC8472 CRC64;
     YVVPAAKLEA IYPKGLRVSI