ID   SELW_PIG                Reviewed;          87 AA.
AC   Q95KL4;
DT   31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 4.
DT   29-SEP-2021, entry version 77.
DE   RecName: Full=Selenoprotein W {ECO:0000312|EMBL:AAK56322.1};
DE            Short=SelW {ECO:0000250|UniProtKB:P63302};
GN   Name=SELENOW {ECO:0000250|UniProtKB:P63302};
GN   Synonyms=SEPW {ECO:0000312|EMBL:AAK56322.1};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Smooth muscle;
RA   Costa N.D., Vorachek W.R., Whanger P.D.;
RT   "Amino acid sequence of porcine selenoprotein W derived from analysis of a
RT   cDNA library prepared from porcine smooth muscle.";
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role as a glutathione (GSH)-dependent antioxidant.
CC       May be involved in a redox-related process. May play a role in the
CC       myopathies of selenium deficiency (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the SelWTH family. Selenoprotein W subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF380118; AAK56322.1; -; mRNA.
DR   RefSeq; NP_999142.1; NM_213977.1.
DR   STRING; 9823.ENSSSCP00000026215; -.
DR   PaxDb; Q95KL4; -.
DR   PeptideAtlas; Q95KL4; -.
DR   PRIDE; Q95KL4; -.
DR   GeneID; 397032; -.
DR   CTD; 6415; -.
DR   eggNOG; ENOG502S9W8; Eukaryota.
DR   InParanoid; Q95KL4; -.
DR   OrthoDB; 1594709at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016209; F:antioxidant activity; IEA:UniProtKB-KW.
DR   GO; GO:0010269; P:response to selenium ion; IBA:GO_Central.
DR   InterPro; IPR011893; Selenoprotein_Rdx-typ.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF10262; Rdx; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR02174; CXXU_selWTH; 1.
PE   3: Inferred from homology;
KW   Antioxidant; Cytoplasm; Glutathionylation; Redox-active center;
KW   Reference proteome; Selenocysteine.
FT   CHAIN           1..87
FT                   /note="Selenoprotein W"
FT                   /id="PRO_0000097681"
FT   NON_STD         13
FT                   /note="Selenocysteine"
FT   MOD_RES         37
FT                   /note="S-glutathionyl cysteine"
FT                   /evidence="ECO:0000250"
FT   CROSSLNK        10..13
FT                   /note="Cysteinyl-selenocysteine (Cys-Sec); redox-active"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   87 AA;  9345 MW;  F91C8FA0F8E90E23 CRC64;
     MGVAVRVVYC GAUGYKSKYL QLKKKLEDEF PGRLDICGEG TPQVTGFFEV LVAGKLVHSK
     KGGDGYVDTE SKFLKLVAAI KAALAQG