ID   SELX_STAA8              Reviewed;         203 AA.
AC   Q2G107;
DT   03-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Enterotoxin-like toxin X {ECO:0000250|UniProtKB:G0Z026};
GN   Name=selX {ECO:0000250|UniProtKB:G0Z026}; OrderedLocusNames=SAOUHSC_00354;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- FUNCTION: Plays a role in the inhibition of the host innate immune
CC       system. Inhibits phagocytosis and killing by human neutrophils by
CC       interacting with multiple neutrophil surface glycoproteins in a sialic
CC       acid-dependent manner. {ECO:0000250|UniProtKB:A0A0H3K6X4}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q2G0X7}.
CC   -!- INDUCTION: Under the control of the Staphylococcus aureus exotoxin
CC       expression (Sae) two component gene regulatory system.
CC       {ECO:0000250|UniProtKB:A0A0H3K6X4}.
CC   -!- DOMAIN: The C-terminal domain contains a V-shape binding site for
CC       sialyl Lewis X. {ECO:0000250|UniProtKB:A0A0H3K6X4}.
CC   -!- SIMILARITY: Belongs to the staphylococcal/streptococcal toxin family.
CC       {ECO:0000305}.
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DR   EMBL; CP000253; ABD29521.1; -; Genomic_DNA.
DR   RefSeq; WP_000475326.1; NZ_LS483365.1.
DR   RefSeq; YP_498943.1; NC_007795.1.
DR   AlphaFoldDB; Q2G107; -.
DR   SMR; Q2G107; -.
DR   EnsemblBacteria; ABD29521; ABD29521; SAOUHSC_00354.
DR   GeneID; 3921827; -.
DR   KEGG; sao:SAOUHSC_00354; -.
DR   PATRIC; fig|93061.5.peg.324; -.
DR   eggNOG; ENOG503058P; Bacteria.
DR   HOGENOM; CLU_127691_0_0_9; -.
DR   OMA; HLEGTYR; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR016091; SuperAg_toxin_C.
DR   SUPFAM; SSF54334; SSF54334; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Secreted.
FT   CHAIN           1..203
FT                   /note="Enterotoxin-like toxin X"
FT                   /id="PRO_0000447513"
SQ   SEQUENCE   203 AA;  23165 MW;  3E297272D8E9B772 CRC64;
     MFKKYDSKNS IVLKSILSLG IIYGGTFGIY PKADASTQNS SSVQDKQLQK VEEVPNNSEK
     ALVKKLYDRY SKDTINGKSN KSRNWVYSER PLNENQVRIH LEGTYTVAGR VYTPKRNITL
     NKEVVTLKEL DHIIRFAHIS YGLYMGEHLP KGNIVINTKD GGKYTLESHK ELQKDRENVK
     INTADIKNVT FKLVKSVNDI EQV