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SEM1A_TRICF
ID   SEM1A_TRICF             Reviewed;         712 AA.
AC   Q26972;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Semaphorin-1A;
DE   AltName: Full=Semaphorin-I;
DE   Flags: Precursor;
GN   Name=SEMA-1A; Synonyms=TSEMA-I;
OS   Tribolium confusum (Confused flour beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX   NCBI_TaxID=7071;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=8269517; DOI=10.1016/0092-8674(93)90625-z;
RA   Kolodkin A.L., Matthes D.J., Goodman C.S.;
RT   "The semaphorin genes encode a family of transmembrane and secreted growth
RT   cone guidance molecules.";
RL   Cell 75:1389-1399(1993).
CC   -!- FUNCTION: Plays a role in growth cones guidance.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC   -!- SIMILARITY: Belongs to the semaphorin family. {ECO:0000305}.
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DR   EMBL; L26080; AAA16609.1; -; mRNA.
DR   PIR; A49423; A49423.
DR   AlphaFoldDB; Q26972; -.
DR   SMR; Q26972; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   CDD; cd11237; Sema_1A; 1.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR042068; SEM1A_sema_dom.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; PTHR11036; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF101912; SSF101912; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Disulfide bond; Glycoprotein;
KW   Membrane; Neurogenesis; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..712
FT                   /note="Semaphorin-1A"
FT                   /id="PRO_0000032299"
FT   TOPO_DOM        21..601
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        602..622
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        623..712
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          21..483
FT                   /note="Sema"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT   CARBOHYD        42
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        69
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        161
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        265
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..105
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT   DISULFID        123..132
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT   DISULFID        242..357
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT   DISULFID        266..316
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT   DISULFID        486..503
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT   DISULFID        495..512
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
SQ   SEQUENCE   712 AA;  79752 MW;  C0734FE5B9C09FE3 CRC64;
     MVVKILVWSI CLIALCHAWM PDSSSKLINH FKSVESKSFT GNATFPDHFI VLNQDETSIL
     VGGRNRVYNL SIFDLSERKG GRIDWPSSDA HGQLCILKGK TDDDCQNYIR ILYSSEPGKL
     VICGTNSYKP LCRTYAFKEG KYLVEKEVEG IGLCPYNPEH NSTSVSYNGQ LFSATVADFS
     GGDPLIYREP QRTELSDLKQ LNAPNFVNSV AYGDYIFFFY RETAVEYMNC GKVIYSRVAR
     VCKDDKGGPH QSRDRWTSFL KARLNCSIPG EYPFYFDEIQ STSDIVEGRY NSDDSKKIIY
     GILTTPVNAI GGSAICAYQM ADILRVFEGS FKHQETINSN WLPVPQNLVP EPRPGQCVRD
     SRILPDKNVN FIKTHSLMED VPALFGKPVL VRVSLQYRFT AITVDPQVKT INNQYLDVLY
     IGTDDGKVLK AVNIPKRHAK ALLYRKYRTS VHPHGAPVKQ LKIAPGYGKV VVVGKDEIRL
     ANLNHCASKT RCKDCVELQD PHCAWDAKQN LCVSIDTVTS YRFLIQDVVR GDDNKCWSPQ
     TDKKTVIKNK PSEVENEITN SIDEKDLDSS DPLIKTGLDD DSDCDPVSEN SIGGCAVRQQ
     LVIYTAGTLH IVVVVVSIVG LFSWLYSGLS VFAKFHSDSQ YPEAPFIEQH NHLERLSANQ
     TGYLTPRANK AVNLVVKVSS STPRPKKDNL DVSKDLNIAS DGTLQKIKKT YI
 
 
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