SEM1A_TRICF
ID SEM1A_TRICF Reviewed; 712 AA.
AC Q26972;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Semaphorin-1A;
DE AltName: Full=Semaphorin-I;
DE Flags: Precursor;
GN Name=SEMA-1A; Synonyms=TSEMA-I;
OS Tribolium confusum (Confused flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7071;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RX PubMed=8269517; DOI=10.1016/0092-8674(93)90625-z;
RA Kolodkin A.L., Matthes D.J., Goodman C.S.;
RT "The semaphorin genes encode a family of transmembrane and secreted growth
RT cone guidance molecules.";
RL Cell 75:1389-1399(1993).
CC -!- FUNCTION: Plays a role in growth cones guidance.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- SIMILARITY: Belongs to the semaphorin family. {ECO:0000305}.
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DR EMBL; L26080; AAA16609.1; -; mRNA.
DR PIR; A49423; A49423.
DR AlphaFoldDB; Q26972; -.
DR SMR; Q26972; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd11237; Sema_1A; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR042068; SEM1A_sema_dom.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; PTHR11036; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF101912; SSF101912; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Disulfide bond; Glycoprotein;
KW Membrane; Neurogenesis; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..712
FT /note="Semaphorin-1A"
FT /id="PRO_0000032299"
FT TOPO_DOM 21..601
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 602..622
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 623..712
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 21..483
FT /note="Sema"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 69
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 265
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..105
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT DISULFID 123..132
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT DISULFID 242..357
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT DISULFID 266..316
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT DISULFID 486..503
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT DISULFID 495..512
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
SQ SEQUENCE 712 AA; 79752 MW; C0734FE5B9C09FE3 CRC64;
MVVKILVWSI CLIALCHAWM PDSSSKLINH FKSVESKSFT GNATFPDHFI VLNQDETSIL
VGGRNRVYNL SIFDLSERKG GRIDWPSSDA HGQLCILKGK TDDDCQNYIR ILYSSEPGKL
VICGTNSYKP LCRTYAFKEG KYLVEKEVEG IGLCPYNPEH NSTSVSYNGQ LFSATVADFS
GGDPLIYREP QRTELSDLKQ LNAPNFVNSV AYGDYIFFFY RETAVEYMNC GKVIYSRVAR
VCKDDKGGPH QSRDRWTSFL KARLNCSIPG EYPFYFDEIQ STSDIVEGRY NSDDSKKIIY
GILTTPVNAI GGSAICAYQM ADILRVFEGS FKHQETINSN WLPVPQNLVP EPRPGQCVRD
SRILPDKNVN FIKTHSLMED VPALFGKPVL VRVSLQYRFT AITVDPQVKT INNQYLDVLY
IGTDDGKVLK AVNIPKRHAK ALLYRKYRTS VHPHGAPVKQ LKIAPGYGKV VVVGKDEIRL
ANLNHCASKT RCKDCVELQD PHCAWDAKQN LCVSIDTVTS YRFLIQDVVR GDDNKCWSPQ
TDKKTVIKNK PSEVENEITN SIDEKDLDSS DPLIKTGLDD DSDCDPVSEN SIGGCAVRQQ
LVIYTAGTLH IVVVVVSIVG LFSWLYSGLS VFAKFHSDSQ YPEAPFIEQH NHLERLSANQ
TGYLTPRANK AVNLVVKVSS STPRPKKDNL DVSKDLNIAS DGTLQKIKKT YI