ID   SEM1_BOVIN              Reviewed;          70 AA.
AC   Q3ZBR6;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=26S proteasome complex subunit SEM1;
DE   AltName: Full=26S proteasome complex subunit DSS1;
DE   AltName: Full=Split hand/foot malformation type 1 protein homolog;
GN   Name=SEM1; Synonyms=DSS1, SHFDG1, SHFM1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the 26S proteasome, a multiprotein complex
CC       involved in the ATP-dependent degradation of ubiquitinated proteins.
CC       This complex plays a key role in the maintenance of protein homeostasis
CC       by removing misfolded or damaged proteins, which could impair cellular
CC       functions, and by removing proteins whose functions are no longer
CC       required. Therefore, the proteasome participates in numerous cellular
CC       processes, including cell cycle progression, apoptosis, or DNA damage
CC       repair. Component of the TREX-2 complex (transcription and export
CC       complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either
CC       centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-
CC       competent ribonucleoprotein particles (mRNPs) to the nuclear entrance
CC       of the nuclear pore complex (nuclear basket). TREX-2 participates in
CC       mRNA export and accurate chromatin positioning in the nucleus by
CC       tethering genes to the nuclear periphery. Binds and stabilizes BRCA2
CC       and is thus involved in the control of R-loop-associated DNA damage and
CC       thus transcription-associated genomic instability. R-loop accumulation
CC       increases in SEM1-depleted cells. {ECO:0000250|UniProtKB:P60896}.
CC   -!- SUBUNIT: Component of the 19S proteasome regulatory particle complex.
CC       The 26S proteasome consists of a 20S core particle (CP) and two 19S
CC       regulatory subunits (RP). The regulatory particle is made of a lid
CC       composed of 9 subunits including SEM1, a base containing 6 ATPases and
CC       few additional components. Belongs to the TREX-2 complex (transcription
CC       and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1,
CC       and either centrin CETN2 or CETN3. Component of the homologous
CC       recombination repair (HR) complex composed of ERCC5/XPG, BRCA2, PALB2,
CC       DSS1 and RAD51 (By similarity). Interacts with the C-terminal of BRCA2.
CC       {ECO:0000250|UniProtKB:P60896}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P60896}.
CC   -!- SIMILARITY: Belongs to the DSS1/SEM1 family. {ECO:0000305}.
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DR   EMBL; BC103152; AAI03153.1; -; mRNA.
DR   RefSeq; NP_001106788.1; NM_001113317.2.
DR   RefSeq; XP_010815929.1; XM_010817627.2.
DR   RefSeq; XP_010823385.1; XM_010825083.1.
DR   AlphaFoldDB; Q3ZBR6; -.
DR   SMR; Q3ZBR6; -.
DR   STRING; 9913.ENSBTAP00000045834; -.
DR   PaxDb; Q3ZBR6; -.
DR   PRIDE; Q3ZBR6; -.
DR   Ensembl; ENSBTAT00000048868; ENSBTAP00000045834; ENSBTAG00000034496.
DR   Ensembl; ENSBTAT00000066603; ENSBTAP00000074453; ENSBTAG00000052508.
DR   GeneID; 101907965; -.
DR   GeneID; 767981; -.
DR   KEGG; bta:101907965; -.
DR   KEGG; bta:767981; -.
DR   CTD; 7979; -.
DR   VEuPathDB; HostDB:ENSBTAG00000034496; -.
DR   VEuPathDB; HostDB:ENSBTAG00000052508; -.
DR   eggNOG; KOG4764; Eukaryota.
DR   GeneTree; ENSGT00940000162732; -.
DR   HOGENOM; CLU_141774_1_2_1; -.
DR   InParanoid; Q3ZBR6; -.
DR   OMA; TLWENNW; -.
DR   TreeFam; TF314699; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000034496; Expressed in abomasum and 98 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000502; C:proteasome complex; ISS:UniProtKB.
DR   GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:InterPro.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR   GO; GO:0043248; P:proteasome assembly; IEA:InterPro.
DR   InterPro; IPR007834; DSS1_SEM1.
DR   PANTHER; PTHR16771; PTHR16771; 1.
DR   Pfam; PF05160; DSS1_SEM1; 1.
DR   SMART; SM01385; DSS1_SEM1; 1.
PE   3: Inferred from homology;
KW   Nucleus; Proteasome; Reference proteome.
FT   CHAIN           1..70
FT                   /note="26S proteasome complex subunit SEM1"
FT                   /id="PRO_0000250508"
SQ   SEQUENCE   70 AA;  8278 MW;  0E0F58D2F3D9F723 CRC64;
     MSEKKQPVDL GLLEEDDEFE EFPAEDWAGL DEDEDAHVWE DNWDDDNVED DFSNQLRAEL
     EKHGYKMETS